H1-0 and IPO7

Data Source:
HPRD (in vitro)

		H1-0	IPO7
Description		H1.0 linker histone	importin 7
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex	Nuclear Envelope Nuclear Pore Nucleoplasm Cytosol Membrane
	Molecular Function	Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Transporter Activity Protein Binding GTPase Regulator Activity Small GTPase Binding Histone Binding SMAD Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation Nucleosome Assembly Chromatin Silencing Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding	Protein Import Into Nucleus Signal Transduction Viral Process Innate Immune Response Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS			Interleukin-10 levels ( 22205395)
Interacting Genes		21 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP1 PARP2 PRKCB RAD51B XBP1	11 interacting genes: AKTIP H1-0 KPNB1 LIMS1 LINC01554 PTEN RAN RPL23A RPL5 RPS7 SRP19
Entrez ID		3005	10527
HPRD ID		00819	09280
Ensembl ID		ENSG00000189060	ENSG00000205339
Uniprot IDs		P07305	B3KNG9 O95373
PDB IDs		6HQ1 6LA8 6LA9 6N88 6N89
Enriched GO Terms of Interacting Partners?
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