H1-0 and RAD51B

Data Source:
HPRD (in vitro)

		H1-0	RAD51B
Description		H1.0 linker histone	RAD51 paralog B
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleosome Euchromatin Nucleus Nucleoplasm Golgi Apparatus Actin Cytoskeleton Nuclear Body Transcription Repressor Complex	Nucleus Nucleoplasm Replication Fork Rad51B-Rad51C-Rad51D-XRCC2 Complex
	Molecular Function	Minor Groove Of Adenine-thymine-rich DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Nucleosomal DNA Binding	Four-way Junction DNA Binding DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic DNA Fragmentation Nucleosome Assembly Chromatin Silencing Nucleosome Positioning Chromosome Condensation Negative Regulation Of Chromatin Silencing Negative Regulation Of DNA Recombination Positive Regulation Of Transcription Regulatory Region DNA Binding	Double-strand Break Repair Via Homologous Recombination DNA Repair DNA Recombination Reciprocal Meiotic Recombination Blood Coagulation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle
Pathways		Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)	HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Advanced age-related macular degeneration ( 26691988) Adverse response to drug ( 30420678) Age-related macular degeneration ( 23455636) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Asthma ( 31361310 31959851 30929738 27182965 32296059 31619474) Asthma (childhood onset) ( 31036433 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Autoimmune thyroid disease ( 32581359) Basophil percentage of white cells ( 32888494) Blond vs. brown/black hair color ( 30531825) Breast cancer ( 29059683) Breast cancer (male) ( 23001122) Cancer (pleiotropy) ( 27197191) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Granulocyte count ( 27863252) Gut microbiota relative abundance (unclassified genus belonging to family Erysipelotrichaceae) ( 33208821) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hematocrit ( 32888494) Immature fraction of reticulocytes ( 32888494) Lymphocyte counts ( 32888494) Macular thickness ( 30535121) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (thyroid preparations) ( 31015401) Monoclonal gammopathy of undetermined significance ( 30737484) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Nose size ( 27182965) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Primary biliary cholangitis ( 26394269) Primary biliary cirrhosis ( 22961000) Prostate cancer ( 23535732) Red blood cell count ( 32888494 27863252) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systemic lupus erythematosus ( 26502338 28714469) Type 2 diabetes nephropathy ( 30566433) White blood cell count ( 32888494 27863252)
Interacting Genes		21 interacting genes: APP CCNE1 CDK1 CDK2 CDK4 CDK5 FBXO7 GRB2 HPF1 IKBKG IPO5 IPO7 KPNA2 KPNB1 NEDD4L NOA1 PARP1 PARP2 PRKCB RAD51B XBP1	12 interacting genes: ABL1 FAM9B H1-0 H2BC8 H3C1 H4C14 MEOX2 RAD51 RAD51C RAD51D RPAIN SWSAP1
Entrez ID		3005	5890
HPRD ID		00819	04255
Ensembl ID		ENSG00000189060	ENSG00000182185
Uniprot IDs		P07305	A0A024R656 C9JYJ0 O15315
PDB IDs		6HQ1 6LA8 6LA9 6N88 6N89
Enriched GO Terms of Interacting Partners?
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