Wiki-MPM
About
Search
Browse
People
Funding
Updates
Search
PLSCR1 and ABL1
Data Source:
HPRD
(in vivo, in vitro)
PLSCR1
ABL1
Description
phospholipid scramblase 1
ABL proto-oncogene 1, non-receptor tyrosine kinase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Golgi Apparatus
Cytosol
Plasma Membrane
Integral Component Of Plasma Membrane
Membrane
Membrane Raft
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Exosome
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Cytosol
Actin Cytoskeleton
Nuclear Body
Dendrite
Cell Leading Edge
Nuclear Membrane
Protein-containing Complex
Neuronal Cell Body
Perinuclear Region Of Cytoplasm
Postsynapse
Molecular Function
Magnesium Ion Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Virus Receptor Activity
DNA Binding
Nuclease Activity
Epidermal Growth Factor Receptor Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
SH3 Domain Binding
Phospholipid Scramblase Activity
Enzyme Binding
Lead Ion Binding
CD4 Receptor Binding
Mercury Ion Binding
Magnesium Ion Binding
Four-way Junction DNA Binding
Bubble DNA Binding
Phosphotyrosine Residue Binding
DNA Binding
Transcription Coactivator Activity
Actin Monomer Binding
Nicotinate-nucleotide Adenylyltransferase Activity
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Non-membrane Spanning Protein Tyrosine Kinase Activity
Protein Kinase C Binding
Protein Binding
ATP Binding
Protein C-terminus Binding
Kinase Activity
SH3 Domain Binding
Syntaxin Binding
Manganese Ion Binding
Neuropilin Binding
SH2 Domain Binding
Ephrin Receptor Binding
Actin Filament Binding
Mitogen-activated Protein Kinase Binding
Proline-rich Region Binding
Supercoiled DNA Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Phosphatidylserine Biosynthetic Process
Apoptotic Process
Acute-phase Response
Response To Lead Ion
Positive Regulation Of Gene Expression
Plasma Membrane Phospholipid Scrambling
Platelet Activation
Regulation Of Mast Cell Activation
Response To Interferon-beta
Negative Regulation Of Viral Genome Replication
Positive Regulation Of Innate Immune Response
Positive Regulation Of Transcription By RNA Polymerase II
Viral Entry Into Host Cell
Negative Regulation Of Phagocytosis
Defense Response To Virus
Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway
Phosphatidylserine Exposure On Apoptotic Cell Surface
Nucleic Acid Phosphodiester Bond Hydrolysis
Positive Regulation Of Chromosome Separation
Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity
Mitotic Cell Cycle
Neural Tube Closure
B-1 B Cell Homeostasis
Positive Regulation Of Protein Phosphorylation
B Cell Proliferation Involved In Immune Response
Transitional One Stage B Cell Differentiation
Mismatch Repair
Regulation Of Transcription, DNA-templated
Cellular Protein Modification Process
Protein Phosphorylation
Endocytosis
Autophagy
Cellular Response To DNA Damage Stimulus
DNA Damage Induced Protein Phosphorylation
Response To Oxidative Stress
Cell Cycle Arrest
Epidermal Growth Factor Receptor Signaling Pathway
Positive Regulation Of Cytosolic Calcium Ion Concentration
Integrin-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Post-embryonic Development
Regulation Of Autophagy
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Cerebellum Morphogenesis
Negative Regulation Of Cell-cell Adhesion
Microspike Assembly
Actin Cytoskeleton Organization
Regulation Of Endocytosis
Regulation Of Cell Adhesion
Negative Regulation Of BMP Signaling Pathway
Regulation Of Axon Extension
Regulation Of Microtubule Polymerization
Regulation Of Cdc42 Protein Signal Transduction
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-2 Production
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Osteoblast Proliferation
Substrate Adhesion-dependent Cell Spreading
Cellular Response To Oxidative Stress
Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Neuropilin Signaling Pathway
Signal Transduction In Response To DNA Damage
Regulation Of Apoptotic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Endothelial Cell Migration
Establishment Of Protein Localization
Regulation Of T Cell Differentiation
Negative Regulation Of Mitotic Cell Cycle
Positive Regulation Of Mitotic Cell Cycle
Positive Regulation Of Transcription By RNA Polymerase II
Alpha-beta T Cell Differentiation
Protein Autophosphorylation
Spleen Development
Thymus Development
Collateral Sprouting
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Activated T Cell Proliferation
T Cell Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
Neuromuscular Process Controlling Balance
Positive Regulation Of Muscle Cell Differentiation
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Positive Regulation Of Oxidoreductase Activity
Negative Regulation Of Ubiquitin-protein Transferase Activity
Positive Regulation Of Stress Fiber Assembly
Mitochondrial Depolarization
Positive Regulation Of Focal Adhesion Assembly
Bergmann Glial Cell Differentiation
Neuroepithelial Cell Differentiation
Cellular Response To Hydrogen Peroxide
Negative Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of ERK1 And ERK2 Cascade
DNA Conformation Change
Cellular Response To Lipopolysaccharide
Negative Regulation Of Protein Serine/threonine Kinase Activity
Circulatory System Development
Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis
Actin Filament Branching
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Long-term Synaptic Potentiation
Negative Regulation Of Phospholipase C Activity
Positive Regulation Of Neuron Death
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of Extracellular Matrix Organization
Cellular Response To Dopamine
Positive Regulation Of Microtubule Binding
Positive Regulation Of Actin Filament Binding
Regulation Of Modification Of Synaptic Structure
Positive Regulation Of Blood Vessel Branching
Activation Of Protein Kinase C Activity
Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Cell Motility
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Actin Cytoskeleton Reorganization
Negative Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Cellular Senescence
Regulation Of Response To DNA Damage Stimulus
Pathways
Regulation of actin dynamics for phagocytic cup formation
Role of ABL in ROBO-SLIT signaling
Role of ABL in ROBO-SLIT signaling
Myogenesis
Myogenesis
RHO GTPases Activate WASPs and WAVEs
HDR through Single Strand Annealing (SSA)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Cyclin D associated events in G1
RUNX1 regulates transcription of genes involved in differentiation of HSCs
RUNX2 regulates osteoblast differentiation
FCGR3A-mediated phagocytosis
Factors involved in megakaryocyte development and platelet production
Drugs
ATP
Imatinib
Dasatinib
N-[4-Methyl-3-[[4-(3-Pyridinyl)-2-Pyrimidinyl]Amino]Phenyl]-3-Pyridinecarboxamide
Nilotinib
XL228
Bosutinib
2-{[(6-OXO-1,6-DIHYDROPYRIDIN-3-YL)METHYL]AMINO}-N-[4-PROPYL-3-(TRIFLUOROMETHYL)PHENYL]BENZAMIDE
1-[4-(PYRIDIN-4-YLOXY)PHENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]UREA
Myristic acid
PD-166326
5-[3-(2-METHOXYPHENYL)-1H-PYRROLO[2,3-B]PYRIDIN-5-YL]-N,N-DIMETHYLPYRIDINE-3-CARBOXAMIDE
2-amino-5-[3-(1-ethyl-1H-pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethylbenzamide
Regorafenib
Ponatinib
Fostamatinib
Brigatinib
Radotinib
Diseases
Chronic myeloid leukemia (CML)
Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
GWAS
Gut microbiota (beta diversity) (
27723756
)
Coronary artery calcified atherosclerotic plaque score in type 2 diabetes (
29221444
)
Lymphocyte counts (
32888494
)
Monocyte count (
32888494
)
Platelet count (
32888494
)
Red cell distribution width (
32888494
)
Response to amphetamines (
22952603
)
White blood cell count (
32888494
)
Interacting Genes
129 interacting genes:
ABL1
ADAMTSL4
ADCY7
ANXA11
APP
ARNT2
ATG12
ATN1
BACE1
BCL6B
C10orf62
CATSPER1
CCDC33
CCER1
CDC42EP1
CHRD
CNTFR
CPSF6
CRK
CRKL
CRY1
CTBP1-DT
CTSZ
DAZAP2
DDIAS
DEF6
DEPP1
DHRS1
DLK2
DMRT3
DOCK2
DTX2
EFEMP2
EGFR
ENKD1
EP300
ESR2
EWSR1
EXD3
FAM107A
FBLN1
FBXL18
FRAT1
FRS3
GDPD5
GLRX3
GNAI2
GPRIN2
HEY2
HOXA1
HOXA9
HOXB6
HRG
ILF3
INTS11
IP6K2
IQCN
KIF1A
KRTAP10-11
KRTAP10-3
KRTAP10-9
KRTAP4-11
KRTAP4-12
KRTAP4-2
KRTAP5-6
KRTAP9-2
LASP1
LCE2D
LCE3C
LCE4A
LGALS9C
LINC00663
LINC01547
LONRF1
MAPK6
MED15
MGAT5B
MVP
NECAP2
NEU4
NOC4L
NPDC1
NR0B2
NTN4
OGDH
P2RY6
PCED1A
PGLS
PHLDA1
PITX1
PKD2
PLSCR3
PLSCR4
PML
PRKCD
PRR13
RAMAC
RASD1
RBL1
RERE
RGS3
RXRB
SCNM1
SF1
SHC1
SLC25A6
SLC35A2
SLPI
SMARCC1
SMCP
SPATA8
SPG7
SPRY2
SRC
STK16
TFG
TRAF4
TRIM42
VASP
VPS37C
VSIR
YIPF3
ZBTB16
ZNF417
ZNF581
ZNF587
ZNF638
ZNF688
ZNF764
161 interacting genes:
ABI1
ABI2
ABL2
ACTA1
ADAM15
ANAPC15
ANKRA2
APBB1
APP
AR
ARHGAP17
ATM
ATR
BCAR1
BCR
BIN1
BRCA1
BTK
C3
CABLES1
CABLES2
CASP9
CAT
CAV1
CBL
CCND2
CD19
CDK1
CDK5
CDKN1A
CDKN1B
CDON
CREB1
CRK
CRKL
CTNND2
DAPK1
DDB1
DDB2
DENND2B
DOK1
DOK2
DOK3
DVL2
EMD
ENAH
EP300
EPHA3
EPHB2
ERBB2
ERBB3
ERBB4
EVL
FBXO7
GJA8
GPX1
GRB10
GRB2
GRIN2D
GTF2F1
HCK
HIPK2
HUWE1
INPPL1
JAK1
JAK2
JUN
KIT
KRT31
LATS2
LRRK1
MAP4K1
MAP4K5
MAPT
MAVS
MBP
MDM2
MICAL1
MUC1
NCK1
NCOA3
NCSTN
NEDD4
NEDD4L
NEDD9
NFKBIA
NTRK1
PAG1
PAK2
PDE4D
PDGFRB
PIK3R1
PLCG1
PLEKHA4
PLSCR1
POLR2A
PRDX1
PRKD1
PRKDC
PSTPIP1
PTPN12
PTPN18
PTPN6
PXN
RAD51
RAD51B
RAD52
RAD9A
RAN
RAPGEF1
RASA1
RB1
RFX1
RIN1
ROBO1
ROS1
RYBP
SFN
SH3BP1
SH3BP2
SHB
SHD
SHE
SLC9A2
SOCS3
SORBS1
SORBS2
SORBS3
SOS2
SPRR2A
SPTA1
SPTAN1
SRC
SRCIN1
SRPK2
STUB1
TERT
TMPO
TOPBP1
TP53
TP73
TRAF6
TUB
UBC
VAV1
WASF1
WASF2
WASL
WRNIP1
XPO1
XRCC6
YAP1
YTHDC1
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZAP70
ZDHHC16
Entrez ID
5359
25
HPRD ID
08855
01809
Ensembl ID
ENSG00000188313
ENSG00000097007
Uniprot IDs
O15162
A0A024R8E2
P00519
Q59FK4
PDB IDs
1Y2A
1AB2
1ABL
1AWO
1BBZ
1JU5
1OPL
1ZZP
2ABL
2E2B
2F4J
2FO0
2G1T
2G2F
2G2H
2G2I
2GQG
2HIW
2HYY
2HZ0
2HZ4
2HZI
2O88
2V7A
3CS9
3EG0
3EG1
3EG2
3EG3
3EGU
3K2M
3PYY
3QRI
3QRJ
3QRK
3T04
3UE4
3UYO
4J9B
4J9C
4J9D
4J9E
4J9F
4J9G
4J9H
4J9I
4JJB
4JJC
4JJD
4TWP
4WA9
4XEY
4YC8
4ZOG
5DC0
5DC4
5DC9
5HU9
5MO4
5NP2
5OAZ
6AMV
6AMW
6BL8
6NPE
6NPU
6NPV
6XR6
6XR7
6XRG
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?