KAT5 and APLP2

Number of citations of the paper that reports this interaction (PubMedID 14699153)
90

Data Source:
BioGRID (two hybrid)

		KAT5	APLP2
Description		lysine acetyltransferase 5	amyloid beta precursor like protein 2
Image
GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Piccolo NuA4 Histone Acetyltransferase Complex NuA4 Histone Acetyltransferase Complex Perinuclear Region Of Cytoplasm	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Histone Acetyltransferase Activity Protein Binding Acetyltransferase Activity Histone Binding Metal Ion Binding Peptide-lysine-N-acetyltransferase Activity DNA-binding Transcription Factor Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Double-strand Break Repair DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Transcription Of P21 Class Mediator Response To Ionizing Radiation Positive Regulation Of Autophagy Histone Acetylation Peptidyl-lysine Acetylation Negative Regulation Of Interleukin-2 Production Regulation Of Growth Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Estradiol Stimulus Cellular Senescence Positive Regulation Of Protein Acetylation	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity
Pathways		Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex DNA Damage/Telomere Stress Induced Senescence HATs acetylate histones HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Estrogen-dependent gene expression Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Coenzyme A S-Acetyl-Cysteine	Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Acne (severe) ( 24927181) Asthma ( 31619474) Body shape index ( 34021172) Chronic kidney disease ( 20383146) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate ( 31152163) HDL cholesterol ( 24097068) HDL cholesterol levels ( 32203549 28334899) Heel bone mineral density ( 30598549) Refractive error ( 32231278) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Blood protein levels ( 30072576)
Interacting Genes		192 interacting genes: AGO2 ALOX12 ALX1 ANTKMT APBB1 APLP1 APLP2 APP AR ARIH2 ATF3 ATM ATXN1 BACH2 BARD1 BCL3 BLZF1 BMI1 BRCA1 C1orf131 C1orf174 CAVIN1 CBX8 CCDC106 CCDC125 CCDC136 CCNB1 CCT7 CDC42 CDK1 CDK5RAP2 CDKN2A CEP126 CEP70 CREB1 CREBBP CRELD1 CSTF2 DLEU1 DNAAF6 DUSP23 E2F1 E2F4 EDNRA EFNA1 EP300 EP400 EPC1 ESR1 ESR2 ETV6 FAM135B FAM161A FCHO1 GADD45G GAPDH GEMIN7 GET4 GIGYF1 GKAP1 GMCL1 GMCL2 GOLGA2 GSTO1 GTF2E2 H2AC20 H2AC4 H2AX H3-3B H3-4 H3C1 H3C14 H4-16 H4C1 H4C14 HABP4 HAP1 HDAC1 HDAC7 HMBOX1 HNRNPH3 HSF2BP ID3 IFT20 IK IKZF3 IL9R KCTD7 KDM2B KLF4 KPNA3 KPNA4 KPNA5 KPNA6 KRT40 KRTAP10-3 KRTAP10-9 LMNA LONRF1 LRIF1 LRP1 LZTS1 LZTS2 MAD2L1BP MAPRE1 MCC MCPH1 MDFI MDM2 MEOX2 MTUS2 MYC MYOD1 NAP1L5 NDUFA4L2 NDUFV2 NFKB1 NINL NR3C1 ODC1 OGFOD2 PDCD5 PFKP PHC2 PICK1 PITX2 PLA2G4A PLEKHA4 PML POLE2 POLR3F PPARG PPP1R16A PRDM6 PROSER2 PTPN4 PTPRS RB1 RCHY1 RELA RFLNB RGL2 RRM2 SAT1 SCRN2 SERTAD2 SHISA6 SNAPIN SNRPD2 SOX5 SPATA2 SQSTM1 SRF SRSF2 SSX2IP STAT3 STMN3 STX11 SYCE1 SYN1 TAX1BP1 TBX5 TELO2 TFIP11 TMCC2 TNNT1 TP53 TRIB3 TRIM23 TRIM27 TRIM29 TRIM37 TUFT1 UBASH3B UHRF1 UPRT YIF1A YJU2 YWHAG ZBTB1 ZBTB14 ZBTB2 ZBTB8A ZC2HC1C ZEB1 ZNF24 ZNF417 ZNF511 ZNF513 ZNF526 ZNF692 ZSCAN4	24 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 KCNJ1 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 VKORC1 ZNF512B
Entrez ID		10524	334
HPRD ID		03245	00103
Ensembl ID		ENSG00000172977	ENSG00000084234
Uniprot IDs		A0A024R597 A0A024R5E8 Q92993	A0A140VJE9 B4E3I5 Q06481
PDB IDs		2EKO 2OU2 4QQG	5JBT 5TPT
Enriched GO Terms of Interacting Partners?
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