APLP2 and APBB2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		APLP2	APBB2
Description		amyloid beta precursor like protein 2	amyloid beta precursor protein binding family B member 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome	Nucleus Cytoplasm Early Endosome Endoplasmic Reticulum Golgi Apparatus Membrane Lamellipodium Growth Cone Synapse
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding	Amyloid-beta Binding Protein Binding Transcription Factor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Smooth Muscle Contraction Intracellular Signal Transduction Maintenance Of Lens Transparency Positive Regulation Of Transcription By RNA Polymerase II Synapse Organization Negative Regulation Of Cell Cycle Phase Transition
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)	Dental caries ( 23259602) Glaucoma (primary open-angle) ( 31688885) Height ( 28552196) Iris color (L* coordinate) ( 29109912) Opioid sensitivity ( 24143882) Response to citalopram or escitalopram in depression ( 27622933)
Interacting Genes		24 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 KCNJ1 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 VKORC1 ZNF512B	9 interacting genes: APLP2 APP MAPK8 NFKB1 SMAD4 SMURF1 TP53 TRADD WWOX
Entrez ID		334	323
HPRD ID		00103	04088
Ensembl ID		ENSG00000084234	ENSG00000163697
Uniprot IDs		A0A140VJE9 B4E3I5 Q06481	B4DJ88 B4E2F2 G5E9Y1 Q5I0G1 Q92870
PDB IDs		5JBT 5TPT
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
Tagcloud (Intersection) ?