APLP2 and DEDD

Number of citations of the paper that reports this interaction (PubMedID 20195357)
31

Data Source:
BioGRID (pull down)

		APLP2	DEDD
Description		amyloid beta precursor like protein 2	death effector domain containing
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Lumen Plasma Membrane Membrane Integral Component Of Membrane Platelet Alpha Granule Membrane Extracellular Exosome	Nucleolus Cytoplasm
	Molecular Function	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Heparin Binding Identical Protein Binding Transition Metal Ion Binding	DNA Binding Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Endopeptidase Activity	Spermatogenesis Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Catabolic Process Regulation Of Apoptotic Process Decidualization Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I
Pathways		Platelet degranulation Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 30072576)
Interacting Genes		24 interacting genes: AKT1 APBB1 APBB2 APBB3 BRCA1 CDK1 DAB1 DAB2 DEDD ETS1 HGS HLA-A JUN JUNB KAT5 KCNJ1 MAPK8 PIK3CA PRKCA PRNP RPL26 SLC13A1 VKORC1 ZNF512B	24 interacting genes: APLP2 APP BATF2 CASP10 CASP3 CASP8 CFLAR DEDD2 FADD GTF3C1 GTF3C3 HOXD4 IRF9 KRT18 KRT8 MPZ NR1I3 PRRC2C SDHC SHMT1 SLC19A2 SMAD3 UAP1 VPS26A
Entrez ID		334	9191
HPRD ID		00103	06022
Ensembl ID		ENSG00000084234	ENSG00000158796
Uniprot IDs		A0A140VJE9 B4E3I5 Q06481	B1AQP5 O75618
PDB IDs		5JBT 5TPT
Enriched GO Terms of Interacting Partners?
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