CDC5L and SYNE1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CDC5L	SYNE1
Gene Name		cell division cycle 5-like	spectrin repeat containing, nuclear envelope 1
Image
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane LINC Complex Postsynaptic Membrane
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding	Actin Binding Protein Binding Lamin Binding Protein Homodimerization Activity Poly(A) RNA Binding Actin Filament Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint	Nucleus Organization Golgi Organization Establishment Of Nucleus Localization Muscle Cell Differentiation Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	Meiotic synapsis
Drugs
Diseases
GWAS		Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)	Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 21738484) Bipolar disorder and major depressive disorder (combined) ( 20351715) Tonometry ( 17903302)
Protein-Protein Interactions		69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	15 interactors: ACTC1 APC CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 EMD KIAA0368 LMNA MUSK NDEL1 SH3BP5 TNIK
Entrez ID		988	23345
HPRD ID		04184	09762
Ensembl ID		ENSG00000096401	ENSG00000131018
Uniprot IDs		Q99459	Q8NF91
PDB IDs		2DIM 2DIN	4DXR
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport	Cytoskeleton Organization Endomembrane System Organization Microtubule-based Process Nuclear Envelope Disassembly Organelle Organization Microtubule Cytoskeleton Organization Cell Differentiation Membrane Organization Nuclear Envelope Organization Regulation Of Cell Projection Organization Mitotic Nuclear Envelope Reassembly Wnt Signaling Pathway Cell Cycle Process Regulation Of Synapse Organization Nuclear Envelope Reassembly Regulation Of Synapse Structure Or Activity Canonical Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Phosphorylation Striated Muscle Tissue Development Mitotic Cell Cycle Process Muscle Tissue Development Nucleus Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cellular Component Organization Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Cell Cycle Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulation Of Signaling Cardiac Muscle Tissue Development Generation Of Neurons Muscle Structure Development Mitotic Nuclear Envelope Disassembly System Development Regulation Of Cellular Localization Neurogenesis Cellular Localization
Tagcloud ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants
Tagcloud (Difference) ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants
Tagcloud (Intersection) ?