CDC5L and DIXDC1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CDC5L	DIXDC1
Gene Name		cell division cycle 5-like	DIX domain containing 1
Image
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Cytosol Focal Adhesion Neuronal Cell Body Protein Complex Axon Terminus
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding	Actin Binding Protein Binding Protein Domain Specific Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Gamma-tubulin Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint	Cell Cycle Wnt Signaling Pathway Cerebellar Cortex Development Cerebral Cortex Radially Oriented Cell Migration Forebrain Ventricular Zone Progenitor Cell Division Regulation Of Actin Cytoskeleton Organization Negative Regulation Of Neuron Differentiation Positive Regulation Of JNK Cascade Positive Regulation Of Axonogenesis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)
Protein-Protein Interactions		69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	8 interactors: APP ATXN1 AXIN1 CDC5L MAP3K4 NDEL1 ULK2 ZDHHC17
Entrez ID		988	85458
HPRD ID		04184	16804
Ensembl ID		ENSG00000096401	ENSG00000150764
Uniprot IDs		Q99459	E9PRV4 Q155Q3 Q86SR7
PDB IDs		2DIM 2DIN	3PZ7
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport	Developmental Cell Growth Developmental Growth Involved In Morphogenesis Cell Growth Regulation Of Signal Transduction Developmental Growth Regulation Of Developmental Growth Regulation Of Signaling Axon Cargo Transport Response To Light Stimulus Neuron Projection Extension Visual Learning Visual Behavior Positive Regulation Of JUN Kinase Activity Signaling Neuron Differentiation Cell Communication Forebrain Development Regulation Of JUN Kinase Activity Associative Learning Wnt-activated Signaling Pathway Involved In Forebrain Neuron Fate Commitment Canonical Wnt Signaling Pathway Involved In Neural Plate Anterior/posterior Pattern Formation Response To Radiation Growth Regulation Of Phosphorylation Axonogenesis System Development Regulation Of Neuron Differentiation Adult Locomotory Behavior Synaptic Growth At Neuromuscular Junction Male Germ-line Sex Determination Axon Development RNA Processing Positive Regulation Of JNK Cascade Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Cell Size Microtubule-based Transport Regulation Of Phosphorus Metabolic Process Regulation Of Growth Positive Regulation Of Stress-activated MAPK Cascade Cytoskeleton-dependent Intracellular Transport Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Learning Intracellular Transport Positive Regulation Of Catalytic Activity Activation Of MAPK Activity Neuron Projection Morphogenesis Collateral Sprouting In Absence Of Injury Primary Sex Determination Axial Mesoderm Formation Generation Of Neurons
Tagcloud ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	angiogenic array catenin gained gsk3beta hey huaier invasiveness ip1 kill knocking lrp6 mobility motility murr ovarian phosphorylations popularity robiniophila rppa s9 scratch skov3 srb trametes untreated viability wnt5a xenografts
Tagcloud (Difference) ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	angiogenic array catenin gained gsk3beta hey huaier invasiveness ip1 kill knocking lrp6 mobility motility murr ovarian phosphorylations popularity robiniophila rppa s9 scratch skov3 srb trametes untreated viability wnt5a xenografts
Tagcloud (Intersection) ?