SYNE1 and EMD

Number of citations of the paper that reports this interaction (PMID 12163176)
64

Data Source:
HPRD (in vitro)

		SYNE1	EMD
Gene Name		spectrin repeat containing, nuclear envelope 1	emerin
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Cytoplasm Golgi Apparatus Cytoskeleton Integral Component Of Membrane Sarcomere Nuclear Membrane LINC Complex Postsynaptic Membrane	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Microtubule Membrane Integral Component Of Membrane Nuclear Membrane
	Molecular Function	Actin Binding Protein Binding Lamin Binding Protein Homodimerization Activity Poly(A) RNA Binding Actin Filament Binding	Actin Binding Protein Binding Beta-tubulin Binding
	Biological Process	Nucleus Organization Golgi Organization Establishment Of Nucleus Localization Muscle Cell Differentiation Cytoskeletal Anchoring At Nuclear Membrane Nuclear Matrix Anchoring At Nuclear Membrane	Mitotic Cell Cycle Muscle Contraction Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Muscle Organ Development Negative Regulation Of Catenin Import Into Nucleus Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus
Pathways		Meiotic synapsis	Mitotic Prophase Nuclear Envelope Breakdown Depolymerisation of the Nuclear Lamina Nuclear Envelope Reassembly Clearance of Nuclear Envelope Membranes from Chromatin Mitotic Anaphase Initiation of Nuclear Envelope Reformation Mitotic Metaphase and Anaphase Cell Cycle, Mitotic M Phase
Drugs
Diseases
GWAS		Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Bipolar disorder ( 21926972 21738484) Bipolar disorder and major depressive disorder (combined) ( 20351715) Tonometry ( 17903302)
Protein-Protein Interactions		15 interactors: ACTC1 APC CAPN1 CDC42 CDC5L CEP63 DISC1 DTNBP1 EMD KIAA0368 LMNA MUSK NDEL1 SH3BP5 TNIK	36 interactors: ABT1 ACTB ACTG2 AEN AKAP8L BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CEP70 COPS6 CREB3 CTNNBIP1 DPPA4 EFHC2 FATE1 GMCL1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 PAK7 PSME1 SH3GL2 SH3GL3 SYNE1 TRAF3IP3 TRIM42 VAV1 YTHDC1 ZNF165 ZNF232
Entrez ID		23345	2010
HPRD ID		09762	02309
Ensembl ID		ENSG00000131018	ENSG00000102119
Uniprot IDs		Q8NF91	P50402
PDB IDs		4DXR	1JEI 2ODC 2ODG
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organization Endomembrane System Organization Microtubule-based Process Nuclear Envelope Disassembly Organelle Organization Microtubule Cytoskeleton Organization Cell Differentiation Membrane Organization Nuclear Envelope Organization Regulation Of Cell Projection Organization Mitotic Nuclear Envelope Reassembly Wnt Signaling Pathway Cell Cycle Process Regulation Of Synapse Organization Nuclear Envelope Reassembly Regulation Of Synapse Structure Or Activity Canonical Wnt Signaling Pathway Positive Regulation Of Pseudopodium Assembly Regulation Of Protein Phosphorylation Striated Muscle Tissue Development Mitotic Cell Cycle Process Muscle Tissue Development Nucleus Organization Positive Regulation Of Protein Metabolic Process Regulation Of Protein Kinase Activity Mitotic Cell Cycle Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport Regulation Of Attachment Of Spindle Microtubules To Kinetochore Regulation Of Cellular Component Organization Regulation Of Phosphorylation Regulation Of Kinase Activity Regulation Of Cellular Protein Metabolic Process Regulation Of Signal Transduction Cell Cycle Multicellular Organismal Development Regulation Of Phosphorus Metabolic Process Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Regulation Of Protein Metabolic Process Establishment Or Maintenance Of Cell Polarity Regulation Of Signaling Cardiac Muscle Tissue Development Generation Of Neurons Muscle Structure Development Mitotic Nuclear Envelope Disassembly System Development Regulation Of Cellular Localization Neurogenesis Cellular Localization	Mitotic Nuclear Envelope Reassembly Establishment Of Viral Latency Nuclear Envelope Reassembly Regulation Of DNA-templated Transcription, Initiation Nucleus Organization Apoptotic Process Mitotic Nuclear Envelope Disassembly Programmed Cell Death Cell Death Death Nuclear Envelope Disassembly Negative Regulation Of Signal Transduction Sterol Regulatory Element Binding Protein Import Into Nucleus Negative Regulation Of Ligand-dependent Nuclear Receptor Transcription Coactivator Activity
Tagcloud ?		aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants	adopt aforementioned arrangements arylacetamides azabicyclo bicycles bicyclo bicyclononanone bicyclononanones carbonyl diazabicycles diazabicyclononanones dipyridyl enantiomers geometries heterocyclic isoquinolines ketocyclazocine n7 nonan oxa pharmacophoric pm3 protonated protonation semiempirical stereoisomers substituents unravel
Tagcloud (Difference) ?		aimed cdna controls correlation distributed encompasses esr1 follicular genotyped genotyping investigating menstrual menstrually migraine mm mrm pgr plink pmm potentially pure qpcr rs3093664 rs9371601 rstudio snps tnf undertaking variants	adopt aforementioned arrangements arylacetamides azabicyclo bicycles bicyclo bicyclononanone bicyclononanones carbonyl diazabicycles diazabicyclononanones dipyridyl enantiomers geometries heterocyclic isoquinolines ketocyclazocine n7 nonan oxa pharmacophoric pm3 protonated protonation semiempirical stereoisomers substituents unravel
Tagcloud (Intersection) ?