CDC5L and MACF1

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CDC5L	MACF1
Gene Name		cell division cycle 5-like	microtubule-actin crosslinking factor 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Cytoplasm Golgi Apparatus Cytoskeleton Microtubule Plasma Membrane Actin Cytoskeleton Ruffle Membrane
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding	Actin Binding Calcium Ion Binding Protein Binding Microtubule Binding ATPase Activity Poly(A) RNA Binding Actin Filament Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint	Mesoderm Formation Posttranslational Protein Targeting To Membrane Movement Of Cell Or Subcellular Component Cell Cycle Arrest Establishment Or Maintenance Of Cell Polarity Metabolic Process Regulation Of Epithelial Cell Migration Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Regulation Of Microtubule-based Process Wound Healing Golgi To Plasma Membrane Protein Transport Positive Regulation Of Axon Extension Regulation Of Focal Adhesion Assembly
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)	HDL cholesterol ( 20686565)
Protein-Protein Interactions		69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	24 interactors: ACTA1 APC ATF7IP CDC5L CEP63 CNTNAP2 CNTNAP4 DISC1 DTNBP1 ESRRA EXOC1 GOLGA4 JUN MAPK9 MAPRE1 NRCAM NRXN1 NRXN2 PLXND1 PRKCD SKIL TANGO6 TNIK TRAF3IP1
Entrez ID		988	23499
HPRD ID		04184	09750
Ensembl ID		ENSG00000096401	ENSG00000127603
Uniprot IDs		Q99459	Q6ZSD7 Q9UPN3
PDB IDs		2DIM 2DIN
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport	Nervous System Development Generation Of Neurons Neurogenesis Regulation Of Cell Projection Organization Cell Projection Organization System Development Developmental Process Multicellular Organismal Development Vocalization Behavior Protein Localization Regulation Of Cellular Component Organization Cellular Localization Neuron Projection Development Anatomical Structure Development Membrane Organization Synapse Assembly Neuroligin Clustering Organelle Organization Response To Mechanical Stimulus Neuron Development Cellular Protein Localization Gephyrin Clustering Cell Differentiation Signaling Cellular Component Assembly Cell Communication Negative Regulation Of Filopodium Assembly Neuron Differentiation Regulation Of Cell Differentiation Social Behavior Vocal Learning Learning Positive Regulation Of Cell Differentiation Postsynaptic Membrane Assembly Regulation Of Grooming Behavior Synapse Organization Cell Development Regulation Of Neuron Projection Development Postsynaptic Density Protein 95 Clustering Anatomical Structure Formation Involved In Morphogenesis Auditory Behavior Movement Of Cell Or Subcellular Component Regulation Of Signaling Neuronal Ion Channel Clustering Regulation Of Cell Morphogenesis Neuron Cell-cell Adhesion Positive Regulation Of Cell Development Regulation Of Binding Cell Projection Morphogenesis Learning Or Memory
Tagcloud ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn
Tagcloud (Difference) ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	a2 comprehensive cytoskeleton ecm focal genotypes hbv hbx hcc hepatocellular hepg2 hmgb1 lamin lc migration ms nevertheless obscure platform preliminary profile proteasome proteomics psma3 s100a11 s100a4 s100a6 supported turn
Tagcloud (Intersection) ?