CDC5L and AKAP6

Number of citations of the paper that reports this interaction (PMID 17043677)
96

Data Source:
BioGRID (two hybrid)

		CDC5L	AKAP6
Gene Name		cell division cycle 5-like	A kinase (PRKA) anchor protein 6
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Nuclear Envelope Cytoplasm Caveola Junctional Sarcoplasmic Reticulum Membrane Intercalated Disc Sarcoplasmic Reticulum T-tubule Nuclear Membrane Calcium Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding	Protein Binding Adenylate Cyclase Binding Protein Complex Scaffold Protein Kinase A Regulatory Subunit Binding Protein Anchor Ion Channel Binding Protein Kinase A Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint	Action Potential Protein Targeting Regulation Of Protein Kinase A Signaling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum CAMP-mediated Signaling Positive Regulation Of Cell Growth Negative Regulation Of CAMP Biosynthetic Process Positive Regulation Of Protein Phosphatase Type 2B Activity Intracellular Signal Transduction Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of NFAT Protein Import Into Nucleus Regulation Of Membrane Repolarization Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Positive Regulation Of Calcineurin-NFAT Signaling Cascade Cellular Response To CAMP Cellular Response To Cytokine Stimulus Positive Regulation Of Potassium Ion Transmembrane Transport Positive Regulation Of Delayed Rectifier Potassium Channel Activity
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)	Anorexia nervosa ( 21079607) Economic and political preferences (environmentalism) ( 22566634) Fasting insulin-related traits (interaction with BMI) ( 22581228)
Protein-Protein Interactions		69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	7 interactors: CALM1 CDC5L DISC1 DTNBP1 PDE4D PRKAR2A RYR2
Entrez ID		988	9472
HPRD ID		04184	05257
Ensembl ID		ENSG00000096401	ENSG00000151320
Uniprot IDs		Q99459	B2RP22 Q13023
PDB IDs		2DIM 2DIN
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Adrenergic Receptor Signaling Pathway Involved In Heart Process G-protein Coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Calcium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transporter Activity Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction Regulation Of Cation Channel Activity Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Striated Muscle Contraction Intracellular Signal Transduction Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Heart Rate By Chemical Signal Regulation Of Cellular Localization Detection Of Calcium Ion Regulation Of Cell Communication By Electrical Coupling Second-messenger-mediated Signaling Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Adrenergic Receptor Signaling Pathway Cellular Response To Epinephrine Stimulus Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Response To Epinephrine Regulation Of Ion Homeostasis Regulation Of Heart Contraction Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Ion Transport Positive Regulation Of Heart Rate Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Cellular Response To Catecholamine Stimulus Muscle Contraction Positive Regulation Of Heart Contraction Positive Regulation Of Cation Channel Activity Muscle System Process Signaling Response To Organonitrogen Compound Cell Communication Regulation Of Cardiac Muscle Cell Contraction Negative Regulation Of Protein Phosphorylation Activation Of Phospholipase C Activity Positive Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Phospholipase C Activity Positive Regulation Of Transporter Activity Negative Regulation Of Phosphorylation
Tagcloud ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Difference) ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	atf7 atxn1 bmpr2 categorize deltan eef1a1 grip2 gtf2f1 interactors jbd jbds jnk1alpha1 jnk3 jnk3alpha1 jnks kcne4 myo9b nnat pias1 ptgds ptpn2 rabgap1 rusc2 shank1 sumo1 sypl1 tkt topbp1 znf668
Tagcloud (Intersection) ?