CDC5L and RPA3

Number of citations of the paper that reports this interaction (PMID 24332808)
3

Data Source:
BioGRID (pull down)

		CDC5L	RPA3
Gene Name		cell division cycle 5-like	replication protein A3, 14kDa
Image
Gene Ontology Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Nucleolus Cytoplasm Membrane Nuclear Speck Catalytic Step 2 Spliceosome	Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Poly(A) RNA Binding WD40-repeat Domain Binding	Damaged DNA Binding Single-stranded DNA Binding Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome DNA Repair Transcription, DNA-templated Regulation Of Transcription, DNA-templated RNA Splicing Gene Expression Signal Transduction Involved In DNA Damage Checkpoint	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Recombinase Assembly DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Repair Transcription-coupled Nucleotide-excision Repair Base-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, DNA Gap Filling Mismatch Repair Double-strand Break Repair Regulation Of Mitotic Cell Cycle Telomere Maintenance Via Semi-conservative Replication Cellular Response To Heat Regulation Of Cell Proliferation Regulation Of Cellular Response To Heat
Pathways		Processing of Capped Intron-Containing Pre-mRNA mRNA Splicing mRNA Splicing - Major Pathway	HSF1 activation Gap-filling DNA repair synthesis and ligation in TC-NER G2/M Checkpoints Repair synthesis for gap-filling by DNA polymerase in TC-NER Activation of the pre-replicative complex DNA strand elongation Mismatch Repair G1/S Transition Homologous recombination repair of replication-independent double-strand breaks Mitotic G1-G1/S phases Removal of the Flap Intermediate from the C-strand Chromosome Maintenance DNA Replication Pre-Initiation S Phase Removal of the Flap Intermediate Global Genomic NER (GG-NER) Nucleotide Excision Repair Activation of the pre-replicative complex Extension of Telomeres Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) Assembly of the RAD51-ssDNA nucleoprotein complex Telomere Maintenance Activation of ATR in response to replication stress Processing of DNA double-strand break ends Double-Strand Break Repair Dual incision reaction in GG-NER Meiotic recombination Synthesis of DNA Lagging Strand Synthesis Processive synthesis on the C-strand of the telomere Processive synthesis on the lagging strand M/G1 Transition Cellular response to heat stress Regulation of HSF1-mediated heat shock response Telomere C-strand (Lagging Strand) Synthesis Presynaptic phase of homologous DNA pairing and strand exchange Repair synthesis of patch ~27-30 bases long by DNA polymerase Cell Cycle, Mitotic Gap-filling DNA repair synthesis and ligation in GG-NER Homologous DNA pairing and strand exchange Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) Transcription-coupled NER (TC-NER) Homologous Recombination Repair Formation of incision complex in GG-NER Cell Cycle Checkpoints
Drugs
Diseases
GWAS		Osteoarthritis ( 22763110) Stroke (ischemic) ( 22941190)	Insulin-like growth factors ( 21216879)
Protein-Protein Interactions		69 interactors: AKAP6 AKAP9 BCAS2 CALM1 CCDC136 CDK2 CDKN1A CDKN2A CDT1 CTNNBL1 DISC1 DIXDC1 DST EMID1 ERG EXOC1 EXOC7 GLTSCR1L GOLGA2 GOLGA8EP GOLGA8F GRB14 GSE1 HOOK1 KALRN KANSL1 KDM1A KIF3C KIF5B KRT18 LMO2 MACF1 MCM10 MCM3 MCM4 MCM5 MELK MYT1L ORC1 ORC2 ORC5 PCBD2 PDE4DIP PLRG1 PPFIA2 PPP1CA PPP1R13B PPP1R8 PRPF19 PRPF3 RPA1 RPA2 RPA3 SFR1 SH3BP5 SMARCD1 SPTBN1 SYNE1 TRAF3IP1 TRAK1 TRIO TTF2 WWC1 YWHAG YWHAQ YWHAZ ZNF35 ZNF451 ZSCAN1	7 interactors: CDC5L MCM2 PRPF19 RAD51 RPA1 RPA2 RPA4
Entrez ID		988	6119
HPRD ID		04184	01567
Ensembl ID		ENSG00000096401
Uniprot IDs		Q99459	A4D105 P35244
PDB IDs		2DIM 2DIN	1L1O 1QUQ 2PI2 2PQA 2Z6K 3KDF
Enriched GO Terms of Interacting Partners?		Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition G1/S Transition Of Mitotic Cell Cycle Cell Cycle Mitotic Cell Cycle Cell Cycle Process Mitotic Cell Cycle Process DNA Replication DNA-dependent DNA Replication DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication Initiation Organelle Organization Cellular Process DNA Recombinase Assembly Apoptotic Signaling Pathway DNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Positive Regulation Of Potassium Ion Transport Cellular Localization Cellular Nitrogen Compound Metabolic Process Positive Regulation Of Programmed Cell Death Regulation Of Cell Cycle Intracellular Signal Transduction Nitrogen Compound Metabolic Process Positive Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Cellular Metabolic Process Establishment Of Localization In Cell Intrinsic Apoptotic Signaling Pathway Nucleotide-excision Repair, DNA Gap Filling Positive Regulation Of Potassium Ion Transmembrane Transport G2/M Transition Of Mitotic Cell Cycle Nucleotide-excision Repair, DNA Damage Removal Regulation Of Intracellular Transport Negative Regulation Of Cell Cycle Positive Regulation Of Apoptotic Process Telomere Maintenance Via Semi-conservative Replication Regulation Of Potassium Ion Transport Cellular Response To Heat Regulation Of Membrane Repolarization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Cell Cycle Phase Transition RNA Splicing Telomere Maintenance Via Recombination Nuclear DNA Replication Golgi To Plasma Membrane Protein Transport	DNA-dependent DNA Replication Cellular Response To DNA Damage Stimulus DNA Recombinase Assembly Cell Cycle Process DNA Metabolic Process DNA Repair Cell Cycle DNA Replication Cellular Response To Stress Double-strand Break Repair DNA Strand Elongation Involved In DNA Replication Mitotic Recombination DNA Damage Checkpoint DNA Strand Elongation G1/S Transition Of Mitotic Cell Cycle Protein-DNA Complex Assembly Cellular Macromolecular Complex Assembly Cell Cycle Checkpoint DNA Recombination Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Recombinational Repair Response To Stress Nucleotide-excision Repair DNA Unwinding Involved In DNA Replication Regulation Of Double-strand Break Repair Via Homologous Recombination Nucleotide-excision Repair, DNA Gap Filling Nucleobase-containing Compound Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Telomere Maintenance Via Semi-conservative Replication Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Nuclear DNA Replication Telomere Maintenance Via Recombination Cellular Nitrogen Compound Metabolic Process Mitotic Cell Cycle Process Regulation Of Double-strand Break Repair DNA Replication Initiation Regulation Of Cell Cycle Phase Transition Regulation Of Cellular Response To Heat Mitotic Cell Cycle Telomere Maintenance Via Telomere Lengthening Nitrogen Compound Metabolic Process Transcription-coupled Nucleotide-excision Repair Cellular Component Assembly Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Chromosome Organization
Tagcloud ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	analysing arabidopsis atrpa atrpa1a atrpa1b atrpa2a atrpa2b atrpa3a atrpa3b complexes differently electrophoretic heterologous heterotrimeric homologs idea interacts mobility preferentially purification rpa1 rpa2 shift similarity stranded subfunctionalization thaliana theory
Tagcloud (Difference) ?		adjuvant adolescents analyse barcodes cdk4 determining digital encoded helicase histopathologic inactivator malignancy mdm2 nanostring neo networks operative osteosarcoma osteosarcomas paediatric panel quantify rb1 recql4 responded runx2 sporadic tp53 unfavourable	analysing arabidopsis atrpa atrpa1a atrpa1b atrpa2a atrpa2b atrpa3a atrpa3b complexes differently electrophoretic heterologous heterotrimeric homologs idea interacts mobility preferentially purification rpa1 rpa2 shift similarity stranded subfunctionalization thaliana theory
Tagcloud (Intersection) ?