MAPK8IP1 and TIAM1

Number of citations of the paper that reports this interaction (PMID 12024021)
43

Data Source:
HPRD (in vivo)

		MAPK8IP1	TIAM1
Gene Name		mitogen-activated protein kinase 8 interacting protein 1	T-cell lymphoma invasion and metastasis 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Cytosol Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell-cell Contact Zone
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding	Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Phospholipid Binding Rac Guanyl-nucleotide Exchange Factor Activity Ephrin Receptor Binding
	Biological Process	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell-matrix Adhesion Small GTPase Mediated Signal Transduction Axon Guidance Cell Migration Rac Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway
Pathways			Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling EPH-ephrin mediated repulsion of cells NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS			Renal sinus fat ( 22044751)
Protein-Protein Interactions		25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2	25 interactors: ABCA1 ANK1 BTRC CAMK2G CD44 CSNK1A1 EFNB1 EPHA2 HRAS MAPK8IP1 MAPK8IP2 MYC NME1 PARD3 PPP1R9B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 SRC UBC YWHAG
Entrez ID		9479	7074
HPRD ID		05223	02820
Ensembl ID		ENSG00000121653	ENSG00000156299
Uniprot IDs		E9PBB9 Q6NUQ9 Q9UQF2	Q13009
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39	2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P
Enriched GO Terms of Interacting Partners?		JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process	Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Signal Transduction Response To Growth Factor Regulation Of Phosphorylation Signaling Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Blood Coagulation Wound Healing Hemostasis Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Response To Wounding Neurotrophin Signaling Pathway Apoptotic Process Phosphate-containing Compound Metabolic Process Programmed Cell Death Response To Stress Response To Stimulus Cell Death Regulation Of Body Fluid Levels Death Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Defense Response
Tagcloud ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency rffl select span stressors throughput transmit uncharacterized
Tagcloud (Difference) ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency rffl select span stressors throughput transmit uncharacterized
Tagcloud (Intersection) ?