MAPK8IP1 and DUSP16

Number of citations of the paper that reports this interaction (PMID 12524447)
17

Data Source:
HPRD (in vitro, in vivo)

		MAPK8IP1	DUSP16
Gene Name		mitogen-activated protein kinase 8 interacting protein 1	dual specificity phosphatase 16
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cytoplasmic Membrane-bounded Vesicle
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
	Biological Process	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Inactivation Of MAPK Activity Protein Dephosphorylation Dephosphorylation Peptidyl-tyrosine Dephosphorylation MAPK Export From Nucleus MAPK Phosphatase Export From Nucleus, Leptomycin B Sensitive
Pathways
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2	8 interactors: MAPK1 MAPK10 MAPK11 MAPK14 MAPK8 MAPK8IP1 MAPK8IP2 MAPK9
Entrez ID		9479	80824
HPRD ID		05223	09525
Ensembl ID		ENSG00000121653
Uniprot IDs		E9PBB9 Q6NUQ9 Q9UQF2	Q9BY84
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39	2VSW 3TG3
Enriched GO Terms of Interacting Partners?		JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade MAPK Cascade Signal Transduction By Phosphorylation Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway JUN Phosphorylation Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Toll-like Receptor Signaling Pathway Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Positive Regulation Of Innate Immune Response JNK Cascade Regulation Of Innate Immune Response Regulation Of MAPK Cascade Positive Regulation Of Signal Transduction Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Cellular Response To Stress Immune Response-regulating Signaling Pathway Phosphorylation Intracellular Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of Protein Metabolic Process Positive Regulation Of Immune Response Regulation Of Catalytic Activity Regulation Of Phosphorylation Protein Phosphorylation Defense Response Regulation Of MAP Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Phosphorus Metabolic Process Regulation Of Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Signal Transduction Innate Immune Response Phosphate-containing Compound Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Positive Regulation Of Immune System Process
Tagcloud ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	acetylate acetylating acetyltransferase acetyltransferases amine aminoglycoside aminoglycosides antituberculosis crystal eis encodes guided homologous identity lys55 mkp modulates msm msmeg mtb nonpathogenic paromomycin phagocyte phosphatase reflecting released revealing rv2416c smegmatis
Tagcloud (Difference) ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	acetylate acetylating acetyltransferase acetyltransferases amine aminoglycoside aminoglycosides antituberculosis crystal eis encodes guided homologous identity lys55 mkp modulates msm msmeg mtb nonpathogenic paromomycin phagocyte phosphatase reflecting released revealing rv2416c smegmatis
Tagcloud (Intersection) ?