MAPK8IP1 and ARHGEF28

Number of citations of the paper that reports this interaction (PMID 10574993)
20

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		MAPK8IP1	ARHGEF28
Gene Name		mitogen-activated protein kinase 8 interacting protein 1	Rho guanine nucleotide exchange factor (GEF) 28
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding	RNA Binding Rho Guanyl-nucleotide Exchange Factor Activity Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Axon Guidance Central Nervous System Neuron Axonogenesis Positive Regulation Of Rho GTPase Activity Intracellular Signal Transduction Ephrin Receptor Signaling Pathway Neurofilament Cytoskeleton Organization
Pathways			EPHB-mediated forward signaling Axon guidance EPH-Ephrin signaling
Drugs
Diseases
GWAS
Protein-Protein Interactions		25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2	4 interactors: MAPK8IP1 RHOA YWHAE YWHAH
Entrez ID		9479	64283
HPRD ID		05223	15244
Ensembl ID		ENSG00000121653	ENSG00000214944
Uniprot IDs		E9PBB9 Q6NUQ9 Q9UQF2	Q8N1W1
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39
Enriched GO Terms of Interacting Partners?		JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process	Substantia Nigra Development Neural Nucleus Development Midbrain Development Positive Regulation Of Intracellular Transport Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Organelle Organization Regulation Of Intracellular Transport Positive Regulation Of Mitochondrion Organization Intracellular Signal Transduction Action Potential Regulation Of Mitochondrion Organization Regulation Of Establishment Of Protein Localization Negative Regulation Of Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Brain Development Regulation Of Protein Localization Negative Regulation Of Neuron Projection Development Head Development Glucocorticoid Catabolic Process Regulation Of Signal Transduction Negative Regulation Of Cell Projection Organization Regulation Of Ion Transmembrane Transporter Activity Regulation Of Transmembrane Transporter Activity Regulation Of Organelle Organization Central Nervous System Development Regulation Of Signaling Negative Regulation Of Peptidyl-serine Dephosphorylation Regulation Of Heart Rate By Hormone Regulation Of Cellular Localization Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Neuron Differentiation Positive Regulation Of Apoptotic Signaling Pathway Skeletal Muscle Satellite Cell Migration Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Regulation Of Membrane Potential Negative Regulation Of Neurogenesis Regulation Of Apoptotic Process Negative Regulation Of Protein Dephosphorylation Apolipoprotein A-I-mediated Signaling Pathway JUN Phosphorylation Cleavage Furrow Formation Regulation Of Cell Death Generation Of Neurons Negative Regulation Of Cell Development Apoptotic Signaling Pathway Neurogenesis
Tagcloud ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	als approx comprehensive copy destabilizing encodes fals familial fus generate guanine heterozygous homozygosity inclusions kb motor mtsod1 neuron nfl premature rgnef rho sals spinal sporadic taqman tls truncated warranted
Tagcloud (Difference) ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	als approx comprehensive copy destabilizing encodes fals familial fus generate guanine heterozygous homozygosity inclusions kb motor mtsod1 neuron nfl premature rgnef rho sals spinal sporadic taqman tls truncated warranted
Tagcloud (Intersection) ?