TIAM1 and PPP1R9B

Number of citations of the paper that reports this interaction (PMID 12531897)
35

Data Source:
HPRD (in vivo, two hybrid)

		TIAM1	PPP1R9B
Gene Name		T-cell lymphoma invasion and metastasis 1	protein phosphatase 1, regulatory subunit 9B
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytosol Cell-cell Junction Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cell-cell Contact Zone	Protein Phosphatase Type 1 Complex Nucleoplasm Cytoplasm Plasma Membrane Adherens Junction Lamellipodium Filopodium Cortical Actin Cytoskeleton Ruffle Membrane Dendritic Spine Synapse
	Molecular Function	Receptor Signaling Protein Activity Guanyl-nucleotide Exchange Factor Activity Rho Guanyl-nucleotide Exchange Factor Activity Phospholipid Binding Rac Guanyl-nucleotide Exchange Factor Activity Ephrin Receptor Binding	Actin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Cell-matrix Adhesion Small GTPase Mediated Signal Transduction Axon Guidance Cell Migration Rac Protein Signal Transduction Positive Regulation Of Rho GTPase Activity Positive Regulation Of Rac GTPase Activity Positive Regulation Of Apoptotic Process Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Positive Regulation Of Axonogenesis Regulation Of Small GTPase Mediated Signal Transduction Apoptotic Signaling Pathway	Regulation Of Cell Growth By Extracellular Stimulus Regulation Of Protein Phosphorylation Actin Filament Organization Cell Cycle Arrest Regulation Of Exit From Mitosis RNA Splicing Dendrite Development Cell Migration Calcium-mediated Signaling Negative Regulation Of Cell Growth Regulation Of Cell Proliferation Negative Regulation Of Catalytic Activity Filopodium Assembly Regulation Of Synaptic Transmission Cellular Response To Morphine Regulation Of Opioid Receptor Signaling Pathway
Pathways		Signaling by GPCR Signalling by NGF Axon guidance Cell death signalling via NRAGE, NRIF and NADE p75 NTR receptor-mediated signalling Rho GTPase cycle EPHB-mediated forward signaling GPCR downstream signaling EPH-ephrin mediated repulsion of cells NRAGE signals death through JNK Signaling by Rho GTPases EPH-Ephrin signaling G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Renal sinus fat ( 22044751)
Protein-Protein Interactions		25 interactors: ABCA1 ANK1 BTRC CAMK2G CD44 CSNK1A1 EFNB1 EPHA2 HRAS MAPK8IP1 MAPK8IP2 MYC NME1 PARD3 PPP1R9B PRKCA PRKCB PRKCD PRKCE PRKCG PRKCZ RAC1 SRC UBC YWHAG	23 interactors: ACTA1 ADRA1A ADRA1B ADRA2A ADRA2B ADRA2C CCKAR CCKBR CDKN2A CHRM3 DCX DRD2 MAPK1 PPP1CA PPP1CB PPP1CC PPP1R2 PPP1R9A PRKACA RGS2 RPS6KB1 TGOLN2 TIAM1
Entrez ID		7074	84687
HPRD ID		02820	04506
Ensembl ID		ENSG00000156299	ENSG00000108819
Uniprot IDs		Q13009	D3DTX6 Q96SB3
PDB IDs		2D8I 3KZD 3KZE 4GVC 4GVD 4K2O 4K2P
Enriched GO Terms of Interacting Partners?		Regulation Of Phosphorus Metabolic Process Cellular Response To Organic Substance Signal Transduction Response To Growth Factor Regulation Of Phosphorylation Signaling Response To Organic Substance Enzyme Linked Receptor Protein Signaling Pathway Cell Communication Cellular Response To Growth Factor Stimulus Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Phosphorylation Regulation Of MAPK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Intracellular Signal Transduction Cellular Response To Stimulus Regulation Of Signaling Regulation Of Protein Metabolic Process Cell Surface Receptor Signaling Pathway Phosphorylation Intracellular Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Blood Coagulation Wound Healing Hemostasis Cell Cycle Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Neurotrophin TRK Receptor Signaling Pathway Response To Wounding Neurotrophin Signaling Pathway Apoptotic Process Phosphate-containing Compound Metabolic Process Programmed Cell Death Response To Stress Response To Stimulus Cell Death Regulation Of Body Fluid Levels Death Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Regulation Of Cell Death Defense Response	Energy Reserve Metabolic Process Adrenergic Receptor Signaling Pathway Regulation Of Signaling Regulation Of Muscle Contraction Regulation Of Smooth Muscle Contraction Regulation Of Vasoconstriction Regulation Of Signal Transduction Energy Derivation By Oxidation Of Organic Compounds Signal Transduction Cell Surface Receptor Signaling Pathway Activation Of MAPK Activity By Adrenergic Receptor Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Phosphorus Metabolic Process Cell Communication Negative Regulation Of Signaling Regulation Of MAPK Cascade Generation Of Precursor Metabolites And Energy Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Epidermal Growth Factor-activated Receptor Transactivation By G-protein Coupled Receptor Signaling Pathway Regulation Of Hormone Secretion Triglyceride Catabolic Process Positive Regulation Of MAPK Cascade Regulation Of Phosphorylation Receptor Transactivation Acylglycerol Catabolic Process Developmental Process Negative Regulation Of Epinephrine Secretion Response To External Stimulus Regulation Of Kinase Activity Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Glycogen Catabolic Process G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Norepinephrine Secretion Response To Organic Substance Response To Stimulus Positive Regulation Of Signal Transduction Muscle System Process Regulation Of Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Cellular Localization Regulation Of Protein Kinase Activity Regulation Of MAP Kinase Activity System Development Anatomical Structure Development Regulation Of Norepinephrine Secretion Negative Regulation Of Signal Transduction Response To Abiotic Stimulus
Tagcloud ?		biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency rffl select span stressors throughput transmit uncharacterized	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Difference) ?		biosynthesis boosting carefully causative defense es extend generating glycosylphosphatidylinositol live longevity mercaptoethanol mutagenized mutants nadph offers omission oxidase paraquat pigl platform pluripotency rffl select span stressors throughput transmit uncharacterized	accn1 ago arises cgg description disturbed eef1a2 fmr1 fmrp fragile gabrd hes1 inherited intelligence interactive lending lymphoblastoid lymphoblasts males microarrays morphogenesis neurodevelopment overrepresentation retardation syndrome transcriptome trinucleotide unc13b untranslated
Tagcloud (Intersection) ?