MAPK8IP1 and VRK2

Number of citations of the paper that reports this interaction (PMID 18286207)
17

Data Source:
HPRD (in vivo, in vitro)

		MAPK8IP1	VRK2
Gene Name		mitogen-activated protein kinase 8 interacting protein 1	vaccinia related kinase 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Mitochondrial Membrane
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Protein Phosphorylation Endocytosis Regulation Of Cell Shape Viral Process Wnt Signaling Pathway Peptidyl-serine Phosphorylation Cellular Response To Oxidative Stress Regulation Of MAPK Cascade Protein Autophosphorylation Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Schizophrenia ( 19571808)
Protein-Protein Interactions		25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2	10 interactors: CCT2 CCT4 CDC42 LNX1 MAP2K7 MAP3K7 MAPK8IP1 MAPK8IP2 RBX1 TCP1
Entrez ID		9479	7444
HPRD ID		05223	03702
Ensembl ID		ENSG00000121653	ENSG00000028116
Uniprot IDs		E9PBB9 Q6NUQ9 Q9UQF2	Q86Y07
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39	2V62
Enriched GO Terms of Interacting Partners?		JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process	Regulation Of JNK Cascade Regulation Of Stress-activated MAPK Cascade JNK Cascade Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Stress-activated MAPK Cascade Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Toxin Transport Binding Of Sperm To Zona Pellucida Sperm-egg Recognition 'de Novo' Posttranslational Protein Folding MAPK Cascade 'de Novo' Protein Folding Cell-cell Recognition Regulation Of MAPK Cascade Signal Transduction By Phosphorylation Regulation Of JUN Kinase Activity Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Cell Recognition Positive Regulation Of JNK Cascade Single Fertilization Positive Regulation Of MAPK Cascade Positive Regulation Of Kinase Activity Regulation Of Protein Phosphorylation Cellular Protein Metabolic Process Fertilization Positive Regulation Of Transferase Activity Positive Regulation Of Signal Transduction Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Fc Receptor Signaling Pathway Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Protein Folding Cellular Response To Stress Regulation Of MAP Kinase Activity Sexual Reproduction Regulation Of Cell Death Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Protein Metabolic Process Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Phosphorylation TRIF-dependent Toll-like Receptor Signaling Pathway
Tagcloud ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Difference) ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	2p16 2q24 4p15 agencies assisting epilepsies epilepsy ethnically fancl filtering generalised governmental grouping harbouring heritability ie implicating imputation league lumping pcdh7 phenotyped philanthropic pleiotropically protocadherin scn1a splitting standardised unclassified
Tagcloud (Intersection) ?