MAPK8IP1 and LRP8

Number of citations of the paper that reports this interaction (PMID 10827173)
91

Data Source:
BioGRID (two hybrid)

		MAPK8IP1	LRP8
Gene Name		mitogen-activated protein kinase 8 interacting protein 1	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
Image
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Membrane Cytosol Mitochondrial Membrane Dendritic Growth Cone Axonal Growth Cone Cell Body Dentate Gyrus Mossy Fiber Synapse Perinuclear Region Of Cytoplasm	Extracellular Region Microtubule Associated Complex Plasma Membrane Caveola Postsynaptic Density Membrane Integral Component Of Membrane Axon Dendrite Neuronal Cell Body Receptor Complex
	Molecular Function	Protein Kinase Inhibitor Activity MAP-kinase Scaffold Activity Protein Binding JUN Kinase Binding Kinesin Binding Mitogen-activated Protein Kinase Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding	Transmembrane Signaling Receptor Activity Calcium Ion Binding Protein Binding High-density Lipoprotein Particle Binding Kinesin Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Reelin Receptor Activity
	Biological Process	Regulation Of Transcription, DNA-templated JUN Phosphorylation Positive Regulation Of Signal Transduction Vesicle-mediated Transport Negative Regulation Of JUN Kinase Activity Regulation Of JNK Cascade Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Transcription From RNA Polymerase II Promoter Retinoid Metabolic Process Proteolysis Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Signal Transduction Blood Coagulation Phototransduction, Visible Light Cytokine-mediated Signaling Pathway Ammon Gyrus Development Layer Formation In Cerebral Cortex Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Response To Drug Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Synaptic Transmission Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Growth Factor Stimulus Cellular Response To Cholesterol Positive Regulation Of Dendrite Development
Pathways			Visual phototransduction Platelet homeostasis Platelet sensitization by LDL Diseases associated with visual transduction Retinoid metabolism and transport
Drugs
Diseases
GWAS			Body mass index (interaction) ( 23192594)
Protein-Protein Interactions		25 interactors: AKT1 APP ARHGEF28 DUSP16 EGFR ERBB2 KLC1 LRP1 LRP2 LRP8 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAP3K13 MAP3K7 MAPK8 MAPK8IP2 MAPK8IP3 MAPK9 PAX2 RECQL5 SNCA TIAM1 VRK2	19 interactors: ANAPC10 APBA2 APOE APOH CLU DAB1 DLG4 GIPC1 GRIN1 ITGB1BP1 LRPAP1 MAPK8IP1 MAPK8IP2 MYLIP NOS1AP RELN SCN3A SNX17 SYNJ2BP
Entrez ID		9479	7804
HPRD ID		05223	04002
Ensembl ID		ENSG00000121653
Uniprot IDs		E9PBB9 Q6NUQ9 Q9UQF2	Q14114
PDB IDs		2G01 2GMX 2H96 3OXI 3PTG 3VUD 3VUG 3VUH 3VUI 3VUK 3VUL 3VUM 4E73 4G1W 4H39	3A7Q
Enriched GO Terms of Interacting Partners?		JNK Cascade Regulation Of Catalytic Activity Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Signal Transduction By Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Regulation Of Kinase Activity MAPK Cascade Regulation Of MAPK Cascade Positive Regulation Of Protein Kinase Activity Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Kinase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Phosphorus Metabolic Process Regulation Of Signaling Positive Regulation Of Transferase Activity Regulation Of Signal Transduction Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Response To Stress Regulation Of Intracellular Signal Transduction Phosphorylation Intracellular Signal Transduction Cellular Response To Stress Regulation Of JNK Cascade Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Metabolic Process Regulation Of Stress-activated MAPK Cascade Positive Regulation Of MAPK Cascade Signaling Cellular Response To Stimulus Cell Communication Protein Autophosphorylation Response To Light Stimulus Activation Of MAPKK Activity Positive Regulation Of Signal Transduction Signal Transduction Phosphate-containing Compound Metabolic Process Protein Phosphorylation Response To Stimulus Cellular Response To Growth Factor Stimulus Response To Growth Factor Activation Of Protein Kinase Activity Positive Regulation Of Cellular Metabolic Process	Regulation Of Beta-amyloid Clearance Membrane Depolarization Regulation Of Signaling Receptor Clustering Regulation Of Cellular Protein Metabolic Process Regulation Of Membrane Potential Positive Regulation Of Catalytic Activity Regulation Of Synaptic Transmission Positive Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Synaptic Transmission Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Ion Transport Regulation Of Postsynaptic Membrane Potential Regulation Of Catalytic Activity Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Cellular Component Organization Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Ion Transmembrane Transport Regulation Of Protein Kinase Activity Positive Regulation Of Cellular Protein Metabolic Process Postsynaptic Membrane Organization Regulation Of Kinase Activity Lateral Motor Column Neuron Migration Regulation Of Receptor Activity Positive Regulation Of Excitatory Postsynaptic Membrane Potential Positive Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Negative Regulation Of Endothelial Cell Migration Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Spinal Cord Motor Neuron Migration Cell-cell Signaling Positive Regulation Of Protein Modification Process Social Behavior Learning Dendrite Development Regulation Of Ion Transmembrane Transporter Activity Behavior Positive Regulation Of Membrane Potential Regulation Of Transmembrane Transporter Activity Regulation Of Tau-protein Kinase Activity N-methyl-D-aspartate Receptor Clustering Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Epithelial Cell Migration Regulation Of Synaptic Plasticity Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering
Tagcloud ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Difference) ?		advantage alleles cited curative cure curves deemed ductal facilitated genotyped hazards kaplan locally meier metastatic minor noncarriers pc polymorphisms resected rs1124736 rs3824872 rs8064821 snp snps socs3 tag unresected worse	aggregation apoe apoe4 apoer2 apolipoprotein carrier cholesterols cognition conflicting deficits emphasis feature hyperphosphorylated isoform lrp1 memory mounting neurodegeneration neurogenesis neuroinflammation neurovascular plasticity potentiation strongest summarize synaptic syndecan underexplored varepsilon4
Tagcloud (Intersection) ?