RHO and GRK5

Number of citations of the paper that reports this interaction (PMID 8288567)
20

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		RHO	GRK5
Gene Name		rhodopsin	G protein-coupled receptor kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Photoreceptor Outer Segment Photoreceptor Inner Segment Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Golgi-associated Vesicle Membrane Rough Endoplasmic Reticulum Membrane Photoreceptor Outer Segment Membrane Ciliary Membrane Photoreceptor Inner Segment Membrane Photoreceptor Disc Membrane	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane
	Molecular Function	G-protein Coupled Receptor Activity Protein Binding Photoreceptor Activity Retinal Binding Spectrin Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding
	Biological Process	Retinoid Metabolic Process Protein Phosphorylation Organelle Organization G-protein Coupled Receptor Signaling Pathway Visual Perception Phototransduction, Visible Light Red, Far-red Light Phototransduction Rhodopsin Mediated Signaling Pathway Protein-chromophore Linkage Regulation Of Rhodopsin Mediated Signaling Pathway Retina Development In Camera-type Eye	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Cargo trafficking to the periciliary membrane Organelle biogenesis and maintenance Class A/1 (Rhodopsin-like receptors) Opsins VxPx cargo-targeting to cilium Assembly of the primary cilium Metabolic disorders of biological oxidation enzymes GPCR ligand binding Diseases associated with visual transduction Activation of the phototransduction cascade Inactivation, recovery and regulation of the phototransduction cascade GPCR downstream signaling Visual phototransduction The phototransduction cascade The canonical retinoid cycle in rods (twilight vision) G alpha (i) signalling events	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Halothane N-Acetylmethionine 3-[Aminoethylphosphoryl]-[1,2-Di-Palmitoyl]-Sn-Glycerol Phosphonothreonine Beta-D-Mannose Alpha-D-Mannose B-2-Octylglucoside Hexadecanal Palmitic Acid Heptane-1,2,3-Triol Lauryl Dimethylamine-N-Oxide (Hydroxyethyloxy)Tri(Ethyloxy)Octane Heptyl 1-Thiohexopyranoside Phosphonoserine
Diseases
GWAS			Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		10 interactors: ADRBK1 ARR3 DERL1 GNGT1 GRK1 GRK5 GRK6 PPP2CA PRKCA SAG	19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		6010	2869
HPRD ID		01584	02926
Ensembl ID		ENSG00000163914	ENSG00000198873
Uniprot IDs		P08100	P34947
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Rhodopsin Mediated Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Phototransduction, Visible Light Detection Of Visible Light Cellular Response To Light Stimulus Phototransduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Detection Of Light Stimulus Cellular Response To Radiation Signal Transduction Detection Of Abiotic Stimulus Signaling Cell Communication Regulation Of Signal Transduction Negative Regulation Of Signal Transduction G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Signaling Regulation Of Signaling Cellular Response To Stimulus Cell Surface Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Response To Light Stimulus Apoptotic Process Response To Radiation Response To Stimulus Programmed Cell Death Cell Death Death Fibroblast Growth Factor Receptor Signaling Pathway Cellular Protein Metabolic Process Visual Perception Sensory Perception Of Light Stimulus Cellular Response To Fibroblast Growth Factor Stimulus Detection Of Stimulus Response To Fibroblast Growth Factor Cellular Protein Modification Process Regulation Of The Force Of Heart Contraction Inactivation Of MAPK Activity Protein Autophosphorylation Protein Phosphorylation Peptidyl-threonine Phosphorylation Photoreceptor Cell Development Activation Of Phospholipase C Activity Protein Metabolic Process Positive Regulation Of Phospholipase C Activity Nuclear Envelope Organization Negative Regulation Of Apoptotic Process	Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport
Tagcloud ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		3t3 adipocyte already arrested beginning cloned clones differentially earliest ebpalpha hif hsp105 inducers l1 master mrnas nih nineteen place ppargamma2 preadipocyte proliferating regulators rgs2 seemed steps takes tc10 vdr	adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?