GRK5 and AVPR2

Number of citations of the paper that reports this interaction (PMID 10858434)
10

Data Source:
HPRD (in vivo, in vitro)

		GRK5	AVPR2
Gene Name		G protein-coupled receptor kinase 5	arginine vasopressin receptor 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Vasopressin Receptor Activity Protein Binding Peptide Binding
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Regulation Of Systemic Arterial Blood Pressure By Vasopressin Positive Regulation Of Systemic Arterial Blood Pressure Renal Water Homeostasis Water Transport Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity I-kappaB Kinase/NF-kappaB Signaling Excretion Hemostasis Positive Regulation Of Cell Proliferation Positive Regulation Of Gene Expression Telencephalon Development Positive Regulation Of Protein Ubiquitination Interferon-gamma Production Cellular Response To Hormone Stimulus Response To Cytokine Negative Regulation Of Urine Volume Negative Regulation Of Renal Sodium Excretion Positive Regulation Of Vasoconstriction Transmembrane Transport Response To Peptide
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Vasopressin-like receptors G alpha (s) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes Aquaporin-mediated transport GPCR ligand binding GPCR downstream signaling Peptide ligand-binding receptors
Drugs			Desmopressin Vasopressin Conivaptan Terlipressin Tolvaptan
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	7 interactors: ARRB2 AVP C1QTNF1 GNAS GNB1 GNG2 GRK5
Entrez ID		2869	554
HPRD ID		02926	02368
Ensembl ID		ENSG00000198873	ENSG00000126895
Uniprot IDs		P34947	P30518
PDB IDs			4JQI
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cellular Response To Prostaglandin E Stimulus Cellular Response To Prostaglandin Stimulus Response To Prostaglandin E Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cellular Response To Catecholamine Stimulus G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Dopamine Receptor Signaling Pathway Cellular Response To Glucagon Stimulus Platelet Activation Regulation Of Body Fluid Levels Cellular Response To Fatty Acid Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway Response To Glucagon Response To Fatty Acid Generation Of Precursor Metabolites And Energy Blood Coagulation Hemostasis G-protein Coupled Receptor Signaling Pathway Energy Reserve Metabolic Process Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Response To Acid Chemical Wound Healing Cytosolic Calcium Ion Homeostasis Regulation Of Signal Transduction Cell Activation Response To Wounding Renal Water Homeostasis Regulation Of Signaling Negative Regulation Of Mitochondrion Organization Response To Organonitrogen Compound Response To Lipid Chemical Homeostasis Response To Organic Cyclic Compound Cellular Calcium Ion Homeostasis Water Transport Energy Derivation By Oxidation Of Organic Compounds Calcium Ion Homeostasis Cellular Response To Peptide Hormone Stimulus Response To Hormone Fluid Transport Cellular Response To Peptide Apoptotic Process Multicellular Organismal Water Homeostasis Programmed Cell Death Cell Death Death Water Homeostasis
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	aqp2 aquaporin asked congenital d85n ddavp desmopressin details diuretics endocrinology insipidus japan japanese ndi nephrogenic nephrology neurology polyuria prognoses retardation revealing siblings society thiazide uncertainty urologic urological urology vasopressin
Tagcloud (Intersection) ?