GRK5 and TACR1

Number of citations of the paper that reports this interaction (PMID 12067742)
0

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		GRK5	TACR1
Gene Name		G protein-coupled receptor kinase 5	tachykinin receptor 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Cell Body
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Tachykinin Receptor Activity Protein Binding Substance P Receptor Activity
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Aggressive Behavior Acute Inflammatory Response Positive Regulation Of Leukocyte Migration Angiotensin-mediated Drinking Behavior Inflammatory Response Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Tachykinin Receptor Signaling Pathway Long-term Memory Associative Learning Response To Heat Detection Of Abiotic Stimulus Response To Ozone Positive Regulation Of Epithelial Cell Migration Response To Auditory Stimulus Regulation Of Smooth Muscle Cell Migration Positive Regulation Of Synaptic Transmission, Cholinergic Positive Regulation Of Synaptic Transmission, GABAergic Response To Estradiol Response To Progesterone Response To Nicotine Operant Conditioning Positive Regulation Of Renal Sodium Excretion Sperm Ejaculation Eating Behavior Positive Regulation Of Vascular Permeability Response To Morphine Response To Ethanol Positive Regulation Of Action Potential Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Vasoconstriction Positive Regulation Of Saliva Secretion Positive Regulation Of Hormone Secretion Behavioral Response To Pain Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Stress Fiber Assembly Response To Electrical Stimulus Smooth Muscle Contraction Involved In Micturition Positive Regulation Of Uterine Smooth Muscle Contraction
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK	G alpha (q) signalling events G alpha (q) signalling events Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Tachykinin receptors bind tachykinins Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Aprepitant Ketamine Vapreotide
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)	Brain connectivity ( 23471985)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	5 interactors: GPRASP1 GRK5 TAC1 TAC3 TAC4
Entrez ID		2869	6869
HPRD ID		02926	01208
Ensembl ID		ENSG00000198873	ENSG00000115353
Uniprot IDs		P34947	P25103
PDB IDs			2KS9 2KSA 2KSB
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Tachykinin Receptor Signaling Pathway Positive Regulation Of Saliva Secretion Regulation Of Saliva Secretion Positive Regulation Of Digestive System Process G-protein Coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway G-protein Coupled Receptor Catabolic Process Positive Regulation Of Corticosterone Secretion Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Blood Pressure Positive Regulation Of Synaptic Transmission, Cholinergic Regulation Of Corticosterone Secretion Regulation Of Synaptic Transmission, Cholinergic Cell Surface Receptor Signaling Pathway Blood Circulation Positive Regulation Of Secretion Positive Regulation Of Action Potential Negative Regulation Of Heart Rate Positive Regulation Of Renal Sodium Excretion Positive Regulation Of Synaptic Transmission, GABAergic Insemination Receptor Catabolic Process Regulation Of Renal Sodium Excretion Copulation Negative Regulation Of Heart Contraction Regulation Of Excretion Positive Regulation Of Acute Inflammatory Response Endosome To Lysosome Transport Regulation Of Secretion Regulation Of Synaptic Transmission, GABAergic Response To Pain Response To Morphine Positive Regulation Of Transport Positive Regulation Of Stress Fiber Assembly Lysosomal Transport Long-term Memory Signal Transduction Positive Regulation Of Actin Filament Bundle Assembly Mating Positive Regulation Of Lipid Transport Signaling Regulation Of Stress Fiber Assembly Termination Of G-protein Coupled Receptor Signaling Pathway Cell Communication Termination Of Signal Transduction Regulation Of Acute Inflammatory Response Regulation Of Heart Rate
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?