GRK5 and BDKRB2

Number of citations of the paper that reports this interaction (PMID 11517230)
13

Data Source:
HPRD (in vitro, in vivo)

		GRK5	BDKRB2
Gene Name		G protein-coupled receptor kinase 5	bradykinin receptor B2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Protease Binding Phosphatidylinositol Phospholipase C Activity Bradykinin Receptor Activity Protein Binding Type 1 Angiotensin Receptor Binding Protein Heterodimerization Activity
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Smooth Muscle Contraction Inflammatory Response Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Metabolic Process Response To Salt Stress Regulation Of Vasoconstriction Negative Regulation Of Peptidyl-serine Phosphorylation Vasoconstriction Vasodilation Regulation Of Vascular Permeability Arachidonic Acid Secretion Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress By P53 Class Mediator
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	12 interactors: ACE ADRBK1 ADRBK2 AGTR1 GNA11 GRK4 GRK5 GRK6 NOS1 NOS3 PRKCD PTPN11
Entrez ID		2869	624
HPRD ID		02926	00213
Ensembl ID		ENSG00000198873	ENSG00000168398
Uniprot IDs		P34947	P30411
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signaling Regulation Of Vasodilation Negative Regulation Of Signal Transduction Blood Circulation Regulation Of The Force Of Heart Contraction Signal Transduction Regulation Of Signal Transduction Receptor Internalization Blood Coagulation Signaling Hemostasis Regulation Of Blood Pressure Regulation Of Signaling Cell Communication Positive Regulation Of Catalytic Activity Regulation Of The Force Of Heart Contraction By Chemical Signal Regulation Of Body Fluid Levels Positive Regulation Of Phospholipase Activity Wound Healing Arginine Catabolic Process Cellular Response To Stimulus Tachykinin Receptor Signaling Pathway Receptor Metabolic Process Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Positive Regulation Of Guanylate Cyclase Activity Response To Wounding Regulation Of Systemic Arterial Blood Pressure Nitric Oxide Biosynthetic Process Regulation Of Blood Volume By Renin-angiotensin Protein Phosphorylation Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Cell Surface Receptor Signaling Pathway Negative Regulation Of Platelet Activation Cellular Protein Metabolic Process Nitric Oxide Mediated Signal Transduction Desensitization Of G-protein Coupled Receptor Protein Signaling Pathway Cellular Protein Modification Process Positive Regulation Of CGMP Biosynthetic Process Positive Regulation Of CGMP Metabolic Process Arginine Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of MRNA Catabolic Process Regulation Of Catalytic Activity Negative Regulation Of Potassium Ion Transport Regulation Of CGMP Biosynthetic Process
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	arg10 arg9 arrangement b1 bk box consensus des entirely etc exon exons extension exudation flanking hyperalgesia hyperemia intron introns kallidin kinin kininase lys noncoding primer sequenced situated tata
Tagcloud (Intersection) ?