GRK5 and CABP1

Number of citations of the paper that reports this interaction (PMID 10625670)
75

Data Source:
BioGRID (pull down)

		GRK5	CABP1
Gene Name		G protein-coupled receptor kinase 5	calcium binding protein 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Golgi Membrane Extracellular Space Nucleus Cytosol Cytoskeleton Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Cell Junction Dendrite Neuronal Cell Body Protein Complex Postsynaptic Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Enzyme Inhibitor Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Type 3 Metabotropic Glutamate Receptor Binding Protein Homodimerization Activity Ion Channel Binding Calcium-dependent Protein Binding
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Negative Regulation Of Cell Communication By Electrical Coupling Negative Regulation Of Protein Import Into Nucleus Negative Regulation Of Catalytic Activity Negative Regulation Of Voltage-gated Calcium Channel Activity
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	9 interactors: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 NMT1 PPP3R1
Entrez ID		2869	9478
HPRD ID		02926	12025
Ensembl ID		ENSG00000198873	ENSG00000157782
Uniprot IDs		P34947	C9J8G2 Q9NZU7
PDB IDs			2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Inositol Phosphate-mediated Signaling Regulation Of Establishment Of Protein Localization Regulation Of Protein Localization Energy Reserve Metabolic Process Second-messenger-mediated Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Regulation Of Cellular Localization Calcium Ion Transport Into Cytosol Cell Death Cytosolic Calcium Ion Transport Death Regulation Of Insulin Secretion Calcium Ion Transmembrane Transport Cell Surface Receptor Signaling Pathway Regulation Of Peptide Hormone Secretion Fc-epsilon Receptor Signaling Pathway Signal Transduction Regulation Of Protein Transport Regulation Of Hormone Secretion Fc Receptor Signaling Pathway Signaling Cellular Calcium Ion Homeostasis Calcium Ion Transport Energy Derivation By Oxidation Of Organic Compounds Cell Communication Calcium Ion Homeostasis Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Protein Secretion Cellular Metal Ion Homeostasis Cellular Response To Stimulus Generation Of Precursor Metabolites And Energy Apoptotic Process Cellular Cation Homeostasis Cellular Ion Homeostasis Programmed Cell Death Single-organism Behavior Intracellular Signal Transduction Immune Response-regulating Signaling Pathway Metal Ion Homeostasis Regulation Of Signaling Cellular Chemical Homeostasis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Ion Homeostasis Intrinsic Apoptotic Signaling Pathway Behavior Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Secretion Calcium Ion Import Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?