GRK5 and RCVRN

Number of citations of the paper that reports this interaction (PMID 12507501)
2

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRK5	RCVRN
Gene Name		G protein-coupled receptor kinase 5	recoverin
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Dendrite
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Calcium Ion Binding Calcium Sensitive Guanylate Cyclase Activator Activity
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Signal Transduction Visual Perception Phototransduction, Visible Light Rhodopsin Mediated Signaling Pathway Regulation Of Rhodopsin Mediated Signaling Pathway Positive Regulation Of Guanylate Cyclase Activity Regulation Of Calcium Ion Transport
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK	Inactivation, recovery and regulation of the phototransduction cascade Visual phototransduction The phototransduction cascade Diseases associated with visual transduction
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	11 interactors: ADRBK1 CAV1 GIT2 GRK1 GRK5 GRK6 IL15RA PQBP1 SMAD3 TGFBR2 TOP1
Entrez ID		2869	5957
HPRD ID		02926	01558
Ensembl ID		ENSG00000198873
Uniprot IDs		P34947	P35243 Q53XL0
PDB IDs			2D8N
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Termination Of Signal Transduction Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Regulation Of Signal Transduction Phosphorylation Regulation Of The Force Of Heart Contraction By Chemical Signal Tachykinin Receptor Signaling Pathway Regulation Of Signaling Cell Surface Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Wound Healing Programmed Cell Death Cell Death Death Phosphate-containing Compound Metabolic Process Regulation Of The Force Of Heart Contraction Receptor Internalization Response To Stimulus Protein Phosphorylation Peptidyl-threonine Phosphorylation Wnt Signaling Pathway Positive Regulation Of Catalytic Activity Embryonic Cranial Skeleton Morphogenesis Signal Transduction Cardiovascular System Development Regulation Of Membrane Repolarization During Action Potential Positive Regulation Of Transforming Growth Factor Beta3 Production Negative Regulation Of Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Tolerance Induction To Self Antigen Negative Regulation Of The Force Of Heart Contraction By Chemical Signal Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Receptor-mediated Endocytosis Enzyme Linked Receptor Protein Signaling Pathway Camera-type Eye Development Positive Regulation Of Cell Adhesion Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Receptor Metabolic Process Mammary Gland Morphogenesis Eye Development Apoptotic Process Regulation Of Striated Muscle Contraction Negative Regulation Of Cell Death Signaling Organ Morphogenesis Lens Development In Camera-type Eye Positive Regulation Of Hydrolase Activity
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?