GRK5 and SNCG

Number of citations of the paper that reports this interaction (PMID 10852916)
68

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		GRK5	SNCG
Gene Name		G protein-coupled receptor kinase 5	synuclein, gamma (breast cancer-specific protein 1)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane	Cytoplasm Microtubule Organizing Center Spindle Plasma Membrane Neuronal Cell Body Axon Terminus Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding	Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation	Aggressive Behavior Synaptic Transmission Adult Locomotory Behavior Protein Secretion Regulation Of Dopamine Secretion Response To Cocaine Response To Drug Regulation Of Neurotransmitter Secretion Synapse Organization Cellular Response To Hydrostatic Pressure
Pathways		G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R	11 interactors: ADRB2 BUB1B GRK1 GRK5 GRK6 MAPK1 MAPK3 MAPK8 POT1 TERF1 TERF2IP
Entrez ID		2869	6623
HPRD ID		02926	04297
Ensembl ID		ENSG00000198873	ENSG00000173267
Uniprot IDs		P34947	O76070 Q6FHG5
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport	Regulation Of Chromosome Organization Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Organelle Organization Negative Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway RNA-dependent DNA Replication Telomere Maintenance Via Telomere Lengthening Protein Phosphorylation Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Regulation Of Golgi Inheritance Negative Regulation Of Protein Binding Caveolin-mediated Endocytosis Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Capping Toll-like Receptor 9 Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Termination Of Signal Transduction MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Telomere Maintenance Regulation Of Signal Transduction MyD88-dependent Toll-like Receptor Signaling Pathway Phosphorylation Regulation Of Golgi Organization Regulation Of Cellular Component Organization Toll-like Receptor 4 Signaling Pathway Negative Regulation Of Telomerase Activity Regulation Of Signaling Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Binding Negative Regulation Of DNA Metabolic Process Regulation Of Early Endosome To Late Endosome Transport Toll-like Receptor Signaling Pathway Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade Regulation Of Telomerase Activity Regulation Of Catalytic Activity Positive Regulation Of Organelle Organization Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response
Tagcloud ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	advance ak058003 carcinogenesis cpg depleted differentially emerged gc hypoxia intriguingly island lncrna lncrnas mediate mediates metastasis microarrays microenvironmental newly next noncoding normoxia positively regulators rnas synuclein therapeutics upregulated validated
Tagcloud (Difference) ?		adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip	advance ak058003 carcinogenesis cpg depleted differentially emerged gc hypoxia intriguingly island lncrna lncrnas mediate mediates metastasis microarrays microenvironmental newly next noncoding normoxia positively regulators rnas synuclein therapeutics upregulated validated
Tagcloud (Intersection) ?