AVPR1B and GRK5

Number of citations of the paper that reports this interaction (PMID 10858434)
10

Data Source:
HPRD (in vitro, in vivo)

		AVPR1B	GRK5
Gene Name		arginine vasopressin receptor 1B	G protein-coupled receptor kinase 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endosome Plasma Membrane Integral Component Of Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Plasma Membrane Focal Adhesion Nuclear Membrane
	Molecular Function	Vasopressin Receptor Activity Protein Kinase C Binding Peptide Binding	Protein Serine/threonine Kinase Activity G-protein Coupled Receptor Kinase Activity Protein Kinase C Binding Protein Binding ATP Binding Phospholipid Binding
	Biological Process	Regulation Of Systemic Arterial Blood Pressure By Vasopressin G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Cellular Response To Hormone Stimulus Positive Regulation Of Vasoconstriction Response To Peptide	Apoptotic Process Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Tachykinin Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Wnt Signaling Pathway Termination Of G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Protein Autophosphorylation
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Peptide ligand-binding receptors Vasopressin-like receptors Gastrin-CREB signalling pathway via PKC and MAPK Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding	G alpha (q) signalling events G alpha (q) signalling events Signaling by GPCR GPCR downstream signaling Gastrin-CREB signalling pathway via PKC and MAPK
Drugs		Desmopressin Vasopressin Terlipressin
Diseases
GWAS			Obesity-related traits ( 23251661) Type 2 diabetes ( 22961080)
Protein-Protein Interactions		2 interactors: AVP GRK5	19 interactors: ADRB2 AGTR1 AVPR1A AVPR1B AVPR2 BDKRB2 CABP1 CALM1 CAV1 CHRM2 DLGAP2 GIT1 RCVRN RHO SNCA SNCB SNCG TACR1 TBXA2R
Entrez ID		553	2869
HPRD ID		02600	02926
Ensembl ID			ENSG00000198873
Uniprot IDs		P47901	P34947
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transmission Of Nerve Impulse Maternal Aggressive Behavior Positive Regulation Of Cellular PH Reduction Penile Erection Positive Regulation Of Glutamate Secretion Positive Regulation Of Prostaglandin Biosynthetic Process Negative Regulation Of Female Receptivity Hyperosmotic Salinity Response Tachykinin Receptor Signaling Pathway Positive Regulation Of Amino Acid Transport Regulation Of Transmission Of Nerve Impulse Aggressive Behavior Sodium-independent Organic Anion Transport Positive Regulation Of Systemic Arterial Blood Pressure Regulation Of Glutamate Secretion Positive Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Neurological System Process Regulation Of Female Receptivity Maternal Behavior Female Mating Behavior ERK1 And ERK2 Cascade Negative Regulation Of Release Of Cytochrome C From Mitochondria Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Grooming Behavior Apoptotic Process Negative Regulation Of Cell Death Regulation Of Renal Sodium Excretion Copulation Programmed Cell Death Hyperosmotic Response Regulation Of Excretion Cell Death Death Negative Regulation Of Signal Transduction Protein Kinase C Signaling Renal Water Homeostasis Negative Regulation Of Signaling Positive Regulation Of Vasoconstriction Positive Regulation Of Fatty Acid Metabolic Process Vasoconstriction Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Mitochondrion Organization Mating Behavior Response To Salt Stress Protein Phosphorylation Response To Testosterone Positive Regulation Of Blood Pressure Response To Nicotine Social Behavior	Regulation Of Vasoconstriction Positive Regulation Of Vasoconstriction Cytosolic Calcium Ion Homeostasis Blood Circulation G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Ion Homeostasis Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Blood Pressure Signaling Regulation Of Systemic Arterial Blood Pressure Cell Communication Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Response To External Stimulus Metal Ion Homeostasis Regulation Of Catalytic Activity Regulation Of Renal Sodium Excretion Cell Surface Receptor Signaling Pathway Regulation Of Excretion Positive Regulation Of Catalytic Activity Cellular Chemical Homeostasis Regulation Of Systemic Arterial Blood Pressure By Vasopressin Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Ion Homeostasis Regulation Of Phospholipase Activity Chemical Homeostasis Regulation Of Ion Transport Homeostatic Process Positive Regulation Of Blood Pressure Cellular Homeostasis Positive Regulation Of Lyase Activity Response To Abiotic Stimulus Regulation Of Smooth Muscle Contraction Aggressive Behavior Regulation Of Muscle Contraction Regulation Of Cyclase Activity Synaptic Transmission Regulation Of Blood Vessel Size Regulation Of Calcium Ion Transport Regulation Of Tube Size Regulation Of Oxidoreductase Activity Positive Regulation Of Phospholipase Activity Cellular Response To Stimulus Positive Regulation Of Cyclic Nucleotide Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lipase Activity Negative Regulation Of Ion Transport
Tagcloud ?			adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Difference) ?			adrenergic analogs belong betaark calmodulin cam constitute csp desensitization gpcr grk1 grk2 grk4 hippocalcin homologous homologues intrinsically laboratories named ncs photoreceptor potently recoverin rhodopsin subfamilies subfamily ubiquitous vilip
Tagcloud (Intersection) ?