PAK2 and SORBS1

Number of citations of the paper that reports this interaction (PMID 16374509)
26

Data Source:
HPRD (in vitro)

		PAK2	SORBS1
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 2	sorbin and SH3 domain containing 1
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Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System	Smooth Muscle Contraction
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL
Entrez ID		5062	10580
HPRD ID		05428	05587
Ensembl ID		ENSG00000180370	ENSG00000095637
Uniprot IDs		A8K5M4 Q13177	Q9BX66
PDB IDs		3PCS	2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death	Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Intersection) ?