SORBS1 and INSR

Number of citations of the paper that reports this interaction (PMID 11374898)
8

Data Source:
HPRD (in vitro, in vivo)

		SORBS1	INSR
Gene Name		sorbin and SH3 domain containing 1	insulin receptor
Image
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft	Plasma Membrane Integral Component Of Plasma Membrane Insulin Receptor Complex Caveola Endosome Membrane Membrane Intracellular Membrane-bounded Organelle Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding	Protein Tyrosine Kinase Activity Receptor Signaling Protein Tyrosine Kinase Activity Insulin-activated Receptor Activity Insulin-like Growth Factor Receptor Binding Protein Binding ATP Binding GTP Binding Insulin-like Growth Factor I Binding Insulin-like Growth Factor II Binding Phosphatidylinositol 3-kinase Binding Insulin Binding Insulin Receptor Substrate Binding PTB Domain Binding
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Activation Of MAPK Activity Positive Regulation Of Protein Phosphorylation Heart Morphogenesis Carbohydrate Metabolic Process Regulation Of Transcription, DNA-templated G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Insulin Receptor Signaling Pathway Epidermis Development Peptidyl-tyrosine Phosphorylation Transformation Of Host Cell By Virus Signal Transduction By Phosphorylation Male Sex Determination Positive Regulation Of Cell Migration Exocrine Pancreas Development Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Cellular Response To Insulin Stimulus Peptidyl-tyrosine Autophosphorylation Glucose Homeostasis Positive Regulation Of MAPK Cascade Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of DNA Replication Positive Regulation Of Glycolytic Process Positive Regulation Of Mitotic Nuclear Division Regulation Of Embryonic Development Positive Regulation Of Glucose Import Protein Autophosphorylation Positive Regulation Of Developmental Growth Protein Heterotetramerization Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Respiratory Burst Cellular Response To Growth Factor Stimulus
Pathways		Smooth Muscle Contraction	Insulin receptor signalling cascade IRS activation Signal attenuation IRS-related events SHC-related events Insulin receptor recycling SHC activation Signaling by Insulin receptor
Drugs			Insulin Regular Insulin Lispro Insulin Glargine Insulin, porcine Mecasermin Insulin Aspart Insulin Detemir Insulin Glulisine Adenosine-5\'-[Beta, Gamma-Methylene]Triphosphate [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID Insulin, isophane
Diseases
GWAS		Obesity-related traits ( 23251661)	Diabetic retinopathy ( 21441570) Height ( 20881960) Hypothyroidism ( 22493691) Polycystic ovary syndrome ( 22885925) Thyroid hormone levels ( 23408906) Urate levels ( 23263486)
Protein-Protein Interactions		25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	77 interactors: ACP1 ADRB2 AHSG ARF1 ARHGAP26 CALM1 CALM2 CALM3 CAV1 CAV3 CBL CEACAM1 CRK CRKL CSK DOK1 DOK4 DOK5 ENPP1 FABP4 FRS2 GAB1 GNB2L1 GRB10 GRB14 GRB7 HRAS IGF1R IGF2 INS INSRR IRF7 IRS1 IRS2 JAK1 JAK2 KHDRBS1 KRT27 KRT31 MAD2L1 MAPK3 PIK3R1 PIK3R3 PLCG1 PRKCA PRKCD PTK2 PTPN1 PTPN11 PTPN12 PTPN2 PTPN6 PTPRC PTPRF RAF1 RASA1 SH2B1 SH2B2 SHC1 SMAD2 SNX1 SNX2 SNX4 SNX6 SOCS1 SOCS2 SOCS3 SOCS6 SORBS1 SRC STAT5A STAT5B SYNCRIP TEAD1 VAV1 VAV3 YWHAB
Entrez ID		10580	3643
HPRD ID		05587	00975
Ensembl ID		ENSG00000095637	ENSG00000171105
Uniprot IDs		Q9BX66	P06213
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V	1GAG 1I44 1IR3 1IRK 1P14 1RQQ 2AUH 2B4S 2DTG 2HR7 2Z8C 3BU3 3BU5 3BU6 3EKK 3EKN 3ETA 3LOH 3W11 3W12 3W13 3W14 4IBM
Enriched GO Terms of Interacting Partners?		Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Kinase Activity Response To Peptide Hormone Cellular Response To Organonitrogen Compound Response To Peptide Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Signaling Cell Surface Receptor Signaling Pathway Regulation Of Protein Kinase Activity Cellular Response To Organic Substance Response To Organonitrogen Compound Regulation Of Signal Transduction Insulin Receptor Signaling Pathway Response To Hormone Cellular Response To Insulin Stimulus Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Immune System Process Regulation Of Immune Response Regulation Of Protein Phosphorylation Intracellular Signal Transduction Blood Coagulation Hemostasis Response To Insulin Response To Organic Substance Regulation Of Body Fluid Levels Regulation Of Protein Metabolic Process Positive Regulation Of Signal Transduction Wound Healing Signal Transduction Immune System Process Neurotrophin TRK Receptor Signaling Pathway Innate Immune Response Regulation Of Cellular Protein Metabolic Process Regulation Of Catalytic Activity Neurotrophin Signaling Pathway Growth Hormone Receptor Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Cellular Response To Growth Hormone Stimulus Response To Wounding Defense Response Signaling Immune Response-regulating Signaling Pathway
Tagcloud ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Difference) ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling	birthweight cognate curly delays determinant dwarfing edema eliminated embryogenesis embryos epidermis generalized hypoplasia igf1r igf2 igr1r indistinguishable manifested mildly muscles nullizygotes nullizygous ossification phenotypically recognizes retardation solely thin xr
Tagcloud (Intersection) ?