PAK2 and ARHGAP10

Number of citations of the paper that reports this interaction (PMID 15471851)
6

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		PAK2	ARHGAP10
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 2	Rho GTPase activating protein 10
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Rho GTPase Activator Activity Protein Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Apoptotic Process Cytoskeleton Organization Small GTPase Mediated Signal Transduction Positive Regulation Of Rho GTPase Activity Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System	Rho GTPase cycle Regulation of PAK-2p34 activity by PS-GAP/RHG10 Signaling by Rho GTPases Programmed Cell Death Regulation of Apoptosis
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)	Immune reponse to smallpox (secreted IL-12p40) ( 22610502) QT interval ( 20031603)
Protein-Protein Interactions		51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	6 interactors: CDC42 PAK2 PKN1 PKN3 RHOA YWHAQ
Entrez ID		5062	79658
HPRD ID		05428	07949
Ensembl ID		ENSG00000180370	ENSG00000071205
Uniprot IDs		A8K5M4 Q13177	A1A4S6
PDB IDs		3PCS
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death	Substantia Nigra Development Neural Nucleus Development Midbrain Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Locomotion Positive Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Intracellular Signal Transduction Positive Regulation Of Intracellular Transport Cell Migration Cell Motility Positive Regulation Of Cytokinesis Axon Guidance Regulation Of Cytokinesis Regulation Of Intracellular Transport Regulation Of Signal Transduction Signal Transduction T Cell Costimulation Positive Regulation Of Kinase Activity Signaling Regulation Of Signaling Cell Communication Axonogenesis Positive Regulation Of Transferase Activity Ephrin Receptor Signaling Pathway Epithelial Cell Migration Axon Development Epithelium Migration Cell Morphogenesis Involved In Neuron Differentiation Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Chemotaxis Small GTPase Mediated Signal Transduction Positive Regulation Of Cell Death Neuron Projection Morphogenesis Positive Regulation Of JNK Cascade Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Cell Division Regulation Of Establishment Of Protein Localization Positive Regulation Of Stress-activated MAPK Cascade Cellular Response To Stimulus Positive Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Hair Follicle Cell Proliferation Cell Morphogenesis Involved In Differentiation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Transport Regulation Of Protein Kinase Activity Brain Development Positive Regulation Of Intracellular Protein Transport Regulation Of Kinase Activity
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles
Tagcloud (Intersection) ?