PAK2 and DST

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		PAK2	DST
Gene Name		p21 protein (Cdc42/Rac)-activated kinase 2	dystonin
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Plasma Membrane Perinuclear Region Of Cytoplasm	Basement Membrane Nucleus Nuclear Envelope Cytoplasm Endoplasmic Reticulum Membrane Cytosol Intermediate Filament Focal Adhesion Cell Cortex Basal Plasma Membrane Actin Cytoskeleton Microtubule Cytoskeleton Integral Component Of Membrane Cytoplasmic Membrane-bounded Vesicle Z Disc Hemidesmosome Axon Cell Leading Edge H Zone Microtubule Plus-end Intermediate Filament Cytoskeleton Extracellular Vesicular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Tyrosine Kinase Activator Activity Identical Protein Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Homodimerization Activity Microtubule Plus-end Binding
	Biological Process	Mitotic Cell Cycle Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Apoptotic Process Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Signal Transduction Axon Guidance Viral Process Phosphorylation Peptidyl-serine Phosphorylation Signal Transduction By Phosphorylation T Cell Costimulation Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Regulation Of Growth Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Innate Immune Response Protein Autophosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Positive Regulation Of Peptidyl-tyrosine Phosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Microtubule Cytoskeleton Organization Cytoskeleton Organization Cell Cycle Arrest Cell Adhesion Integrin-mediated Signaling Pathway Response To Wounding Maintenance Of Cell Polarity Extracellular Matrix Organization Hemidesmosome Assembly Intermediate Filament Cytoskeleton Organization Cell Motility
Pathways		Regulation of PAK-2p34 activity by PS-GAP/RHG10 Costimulation by the CD28 family Axon guidance HIV Infection FCERI mediated MAPK activation VEGFA-VEGFR2 Pathway Nef and signal transduction Ephrin signaling Activation of Rac VEGFR2 mediated vascular permeability Programmed Cell Death EPH-Ephrin signaling Innate Immune System Generation of second messenger molecules Semaphorin interactions Apoptotic execution phase CD28 co-stimulation Regulation of activated PAK-2p34 by proteasome mediated degradation Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis CD28 dependent Vav1 pathway Stimulation of the cell death response by PAK-2p34 TCR signaling Signaling by VEGF Sema3A PAK dependent Axon repulsion Fc epsilon receptor (FCERI) signaling Signaling by Robo receptor Regulation of Apoptosis Adaptive Immune System	Cell junction organization Type I hemidesmosome assembly
Drugs
Diseases
GWAS		Total ventricular volume ( 21116278)
Protein-Protein Interactions		51 interactors: ABI1 ABI3 ABL1 APP ARHGAP10 ARHGEF6 ARHGEF7 BRAF CASP3 CDC42 DOCK2 DST EIF4B EIF4G1 EP300 FYN GRB2 HCK HIST1H4F LCK LIMK1 LYN MAPK1 MAPK3 MKNK1 MYC MYL2 MYLK NCK1 NPHP1 PACSIN3 RAC1 RAC2 RAF1 RHOJ RIOK3 RPS6 SH3GL2 SH3KBP1 SH3PXD2A SH3RF1 SH3RF3 SNX33 SNX9 SORBS1 SORBS2 SORBS3 SRC SYN1 VIM YES1	26 interactors: APC CALM1 CDC5L CELSR3 CEP63 COL17A1 DCTN1 DISC1 DTNBP1 ERBB2IP EXOC1 ITGB4 ITSN2 KIAA0368 KIAA1549 KRT14 KRT5 MAPK6 NFYC PAK2 PRKAB2 PRKD2 SH3BP5 SMAD9 TNIK TRAF3IP1
Entrez ID		5062	667
HPRD ID		05428	00222
Ensembl ID		ENSG00000180370	ENSG00000151914
Uniprot IDs		A8K5M4 Q13177	B4DGY0 B4DSS9 Q03001 Q6P0N6
PDB IDs		3PCS	3GJO
Enriched GO Terms of Interacting Partners?		Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Endocytosis Movement Of Cell Or Subcellular Component Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Cellular Component Organization Axon Guidance Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Locomotion Cytoskeleton Organization Chemotaxis Phagocytosis Axonogenesis Neurotrophin TRK Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Immune Response-regulating Signaling Pathway ERBB Signaling Pathway Axon Development Cellular Response To Peptide Hormone Stimulus Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Involved In Differentiation Cellular Response To Peptide Cell Projection Organization Actin Filament-based Process Neuron Projection Morphogenesis Signal Transduction Signaling Response To Peptide Hormone Peptidyl-tyrosine Autophosphorylation Cell Communication Innate Immune Response Cellular Response To Organonitrogen Compound Cell Development Cellular Response To Growth Factor Stimulus Apoptotic Process Response To Peptide Intracellular Signal Transduction Actin Cytoskeleton Organization Cell Projection Morphogenesis Regulation Of Immune System Process Cellular Response To Organic Substance Response To Growth Factor Cell Part Morphogenesis Programmed Cell Death	Hemidesmosome Assembly Cell-substrate Junction Assembly Cell Junction Assembly Signaling Organelle Organization Cell Communication Signal Transduction Regulation Of Protein Kinase Activity Regulation Of Protein Phosphorylation Intracellular Signal Transduction Regulation Of Kinase Activity Anatomical Structure Development Regulation Of Phosphorylation Cell Cycle Nervous System Development Developmental Process Cellular Component Assembly Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Epithelium Development Regulation Of Cellular Protein Metabolic Process Microtubule-based Process Cytoskeleton Organization Response To Stimulus Cell Projection Organization Cell Surface Receptor Signaling Pathway Cellular Response To Stimulus Epidermis Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cell Projection Assembly Tissue Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Protein Modification Process Positive Regulation Of Metabolic Process Negative Regulation Of Protein Phosphorylation Microtubule-based Transport Cytoskeleton-dependent Intracellular Transport System Development Regulation Of Catalytic Activity Cellular Localization Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Negative Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Cell Adhesion Regulation Of Signal Transduction
Tagcloud ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked
Tagcloud (Difference) ?		cot densitometry erk2 hog immunoreactivities jnks kinases mapkapk2 mapks mek1 mekkl mkk3 mlk3 mos myocytes pakl phenomena probed proliferate proto raf1 rafb resist rsk1 rsk2 sekl tpl ventricle ventricles	125i alanine amines analogous asked attach attached attaches attempted b2 bradykinin bromide covalently cyanogen disuccinimidyl epsilon exchanged homobifunctional immunoidentification k174a labeling linker lys172 lys174 reacts reagent tartarate tyr8 worked
Tagcloud (Intersection) ?