SORBS1 and PILRA

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		SORBS1	PILRA
Gene Name		sorbin and SH3 domain containing 1	paired immunoglobin-like type 2 receptor alpha
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Stress Fiber Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Plasma Membrane Insulin Receptor Complex Cell-cell Adherens Junction Zonula Adherens Cell-substrate Adherens Junction Focal Adhesion Nuclear Matrix Membrane Raft	Plasma Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Actin Binding SH3/SH2 Adaptor Activity Insulin Receptor Binding Protein Binding Cytoskeletal Protein Binding Protein Kinase Binding	Protein Binding
	Biological Process	Muscle Contraction Cell-matrix Adhesion Insulin Receptor Signaling Pathway Positive Regulation Of Signal Transduction Glucose Transport Cellular Response To Insulin Stimulus Stress Fiber Assembly Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Positive Regulation Of Lipid Biosynthetic Process Focal Adhesion Assembly Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane	Signal Transduction Viral Process
Pathways		Smooth Muscle Contraction
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		25 interactors: ABL1 ACTA1 ADAM15 CBL CDK6 EFNB1 FLOT1 INPPL1 INSM1 INSR KHDRBS1 MAP4K3 MLLT4 PAK2 PGR PILRA PTK2 PXN RPL4 SEMA6A SH2B2 SLC10A3 SRC TENM1 VCL	5 interactors: DNPH1 FCAR PTPN11 PTPN6 SORBS1
Entrez ID		10580	29992
HPRD ID		05587	05631
Ensembl ID		ENSG00000095637	ENSG00000085514
Uniprot IDs		Q9BX66	C9JJ79 Q9UKJ1
PDB IDs		2DL3 2ECZ 2LJ0 2LJ1 2O2W 2O31 2O9S 2O9V
Enriched GO Terms of Interacting Partners?		Cell Development Cell Morphogenesis Involved In Differentiation Response To Stimulus Anatomical Structure Development Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Differentiation Anatomical Structure Morphogenesis Multicellular Organismal Development Developmental Process System Development Axonogenesis Cell Morphogenesis Signal Complex Assembly Axon Development Peptidyl-tyrosine Autophosphorylation Cell Morphogenesis Involved In Neuron Differentiation Cell Projection Organization Signal Transduction Regulation Of Cell Motility Neuron Projection Morphogenesis Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Signal Transduction Neuron Development Regulation Of Locomotion Regulation Of Cellular Component Movement Signaling Cell Surface Receptor Signaling Pathway Tissue Development Cell Communication Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus ERBB Signaling Pathway Nervous System Development Neuron Projection Development Regulation Of Cell Proliferation Neuron Differentiation Cell Projection Morphogenesis Cell Part Morphogenesis Generation Of Neurons Cell Adhesion Adherens Junction Organization Protein Autophosphorylation Cell-substrate Adhesion Regulation Of Cell Adhesion Axon Guidance Response To Organic Substance Neurogenesis Response To Hormone Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction	Abortive Mitotic Cell Cycle Megakaryocyte Development Platelet Formation Platelet Morphogenesis Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Megakaryocyte Differentiation Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Glucose Import Positive Regulation Of Glucose Transport Response To Peptide Hormone Regulation Of Glucose Import Cellular Response To Organonitrogen Compound Response To Peptide T Cell Costimulation Cellular Response To Hormone Stimulus Regulation Of Cytokine-mediated Signaling Pathway Regulation Of Glucose Transport Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Negative Regulation Of Cortisol Secretion Negative Regulation Of Growth Hormone Secretion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Response To Type I Interferon Interferon-gamma-mediated Signaling Pathway Cellular Response To Interferon-gamma Insulin Receptor Signaling Pathway Hematopoietic Progenitor Cell Differentiation Response To Organonitrogen Compound Deoxyribonucleoside Monophosphate Catabolic Process Response To Interferon-gamma Enzyme Linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Glucocorticoid Secretion Response To Hormone Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Cell Adhesion Positive Regulation Of T Cell Activation Regulation Of Cellular Localization Cellular Response To Insulin Stimulus Positive Regulation Of Homotypic Cell-cell Adhesion Leukocyte Migration Bone Development Negative Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Myeloid Cell Differentiation
Tagcloud ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Difference) ?		1n9c acsl3 agpat3 bovinesnp50 bta1 c10 c12 c14 c18 chuk dgat1 echs1 ehhadh groundwork htr1b lipj lipk minpp1 mogat1 nfkb2 osbpl8 oxct1 plink prkg1 scd1 sfa ufa underling unraveling
Tagcloud (Intersection) ?