ITGAM and ICAM1

Number of citations of the paper that reports this interaction (PMID 12208882)
65

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		ITGAM	ICAM1
Gene Name		integrin, alpha M (complement component 3 receptor 3 subunit)	intercellular adhesion molecule 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome
	Molecular Function	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System	Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs			Natalizumab Hyaluronan
Diseases
GWAS		Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)
Protein-Protein Interactions		18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1	12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN
Entrez ID		3684	3383
HPRD ID		00411	00996
Ensembl ID		ENSG00000169896	ENSG00000090339
Uniprot IDs		P11215	B4DQW5 E7ESS4 P05362
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76	1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade	Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3
Tagcloud (Intersection) ?