ICAM1 and IL2RG

Number of citations of the paper that reports this interaction (PMID 1976256)
16

Data Source:
HPRD (in vivo)

		ICAM1	IL2RG
Gene Name		intercellular adhesion molecule 1	interleukin 2 receptor, gamma
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding	Interleukin-2 Receptor Activity Interleukin-4 Receptor Activity Interleukin-7 Receptor Activity Protein Binding Interleukin-2 Binding Interleukin-7 Binding
	Biological Process	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Immune Response Signal Transduction Viral Process Interleukin-4-mediated Signaling Pathway Interleukin-2-mediated Signaling Pathway Interleukin-7-mediated Signaling Pathway
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling Interleukin-7 signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Natalizumab Hyaluronan
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)
Protein-Protein Interactions		12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN	24 interactors: AXL CAPNS1 ICAM1 IL15 IL15RA IL2 IL2RB IL4 IL4R IL7 IL7R IL9R JAK1 JAK3 KRTAP10-3 NOTCH2NL PTPRJ SHB SHC1 STAT1 STAT5A STK4 WWP1 WWP2
Entrez ID		3383	3561
HPRD ID		00996	02391
Ensembl ID		ENSG00000090339	ENSG00000147168
Uniprot IDs		B4DQW5 E7ESS4 P05362	P31785 Q5FC09
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX	1ILL 1ILM 1ILN 1ITE 2B5I 2ERJ 3BPL 3QAZ 3QB7 4GS7
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation	Regulation Of Lymphocyte Differentiation Positive Regulation Of Lymphocyte Differentiation Positive Regulation Of Cell Activation Regulation Of T Cell Differentiation Response To Cytokine Regulation Of Immune System Process Cellular Response To Cytokine Stimulus Cytokine-mediated Signaling Pathway Regulation Of Cell Activation Positive Regulation Of T Cell Activation Signaling Positive Regulation Of Homotypic Cell-cell Adhesion Cell Communication Positive Regulation Of Cell Adhesion Lymphocyte Differentiation Positive Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Surface Receptor Signaling Pathway Signal Transduction Lymphocyte Activation Regulation Of Cell Adhesion Regulation Of Cell Proliferation Regulation Of Immune Response Positive Regulation Of T Cell Differentiation Positive Regulation Of Immune System Process Regulation Of T Cell Activation Cell Activation Leukocyte Activation Immune Response Leukocyte Differentiation Immune System Process Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Cell-cell Adhesion Negative Regulation Of Immune System Process Cellular Response To Organic Substance Hemopoiesis Cellular Response To Stimulus T Cell Differentiation T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Response To Organic Substance Immune System Development Leukocyte Cell-cell Adhesion Positive Regulation Of T Cell Proliferation Homotypic Cell-cell Adhesion Single Organismal Cell-cell Adhesion Response To Stimulus
Tagcloud ?		baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Difference) ?		baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3	1ada 1p24 antiretroviral atazanavir atv boosted capacities carriage coating depots fa folic loads mirrored nanoart nanocrystals nanoformulated p407 parafollicular paralleled permit pharmacodynamic poloxamer prkdc reconstituted ritonavir szj tm1wjl untargeted
Tagcloud (Intersection) ?