ITGAM and ICAM2

Number of citations of the paper that reports this interaction (PMID 10352278)
5

Data Source:
HPRD (in vitro)

		ITGAM	ICAM2
Gene Name		integrin, alpha M (complement component 3 receptor 3 subunit)	intercellular adhesion molecule 2
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Uropod Plasma Membrane Integral Component Of Plasma Membrane Membrane Extracellular Vesicular Exosome
	Molecular Function	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity	Integrin Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration	Cell Adhesion Single Organismal Cell-cell Adhesion Extracellular Matrix Organization Regulation Of Immune Response
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System	Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1	7 interactors: ATP13A2 CD209 EZR ITGAM ITGB2 MSN RDX
Entrez ID		3684	3384
HPRD ID		00411	00888
Ensembl ID		ENSG00000169896	ENSG00000108622
Uniprot IDs		P11215	P13598 Q6FHE2
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76	1ZXQ
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade	Leukocyte Cell-cell Adhesion Establishment Of Endothelial Barrier Single Organismal Cell-cell Adhesion Endothelial Cell Development Membrane To Membrane Docking Endothelial Cell Differentiation Endothelium Development Leukocyte Migration Involved In Inflammatory Response Microvillus Assembly Microvillus Organization Cell Adhesion Cellular Extravasation Activated T Cell Proliferation Epithelial Cell Development Leukocyte Migration Tissue Development Neutrophil Chemotaxis Neutrophil Migration Granulocyte Chemotaxis T Cell Proliferation Locomotion Toll-like Receptor 4 Signaling Pathway Regulation Of Immune System Process Membrane Docking Leukocyte Chemotaxis Epithelial Cell Differentiation Toll-like Receptor Signaling Pathway Lymphocyte Proliferation Mononuclear Cell Proliferation Movement Of Cell Or Subcellular Component Integrin-mediated Signaling Pathway Chemotaxis Leukocyte Proliferation Microglia Development Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Activation Of Innate Immune Response Peptide Antigen Transport Cell Chemotaxis Regulation Of Cell Shape Cell Development Cell Differentiation Positive Regulation Of Innate Immune Response Innate Immune Response Cell Migration Cellular Response To Manganese Ion Ectodermal Cell Differentiation Cell Motility Immune System Process Virion Attachment To Host Cell
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	aap aat affymetrix alopecia areata ccl5 cd27 cx3cl1 cxcl10 cxcr5 degs distinctly ereg etiopathogenesis favoring fgf18 fgf5 foxc2 hair hu95a icam3 ighg3 ighm il7r lck lesional separating sfn v2
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	aap aat affymetrix alopecia areata ccl5 cd27 cx3cl1 cxcl10 cxcr5 degs distinctly ereg etiopathogenesis favoring fgf18 fgf5 foxc2 hair hu95a icam3 ighg3 ighm il7r lck lesional separating sfn v2
Tagcloud (Intersection) ?