ITGAM and AUP1

Number of citations of the paper that reports this interaction (PMID 12042322)
6

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		ITGAM	AUP1
Gene Name		integrin, alpha M (complement component 3 receptor 3 subunit)	ancient ubiquitous protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)
Protein-Protein Interactions		18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1	7 interactors: ITGA1 ITGA2 ITGA2B ITGA5 ITGAM ITGAV RNF11
Entrez ID		3684	550
HPRD ID		00411	03892
Ensembl ID		ENSG00000169896	ENSG00000115307
Uniprot IDs		P11215	Q9Y679
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76	2EKF
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade	Integrin-mediated Signaling Pathway Extracellular Matrix Organization Extracellular Structure Organization Blood Coagulation Hemostasis Cell-substrate Adhesion Regulation Of Body Fluid Levels Wound Healing Chemotaxis Response To Wounding Axon Guidance Cell-matrix Adhesion Cell Adhesion Axonogenesis Locomotion Axon Development Cell Morphogenesis Involved In Neuron Differentiation Leukocyte Migration Neuron Projection Morphogenesis Movement Of Cell Or Subcellular Component Cell Morphogenesis Involved In Differentiation Neurogenesis Neuron Projection Development Cell Migration Cell Projection Morphogenesis Positive Regulation Of Cell Migration Cell Part Morphogenesis Positive Regulation Of Cell Motility Cell Development Response To External Stimulus Positive Regulation Of Cellular Component Movement Cell Motility Positive Regulation Of Locomotion Neuron Development Cell Morphogenesis Neuron Differentiation Cell Projection Organization Nervous System Development Formation Of Primary Germ Layer Cell Adhesion Mediated By Integrin Single Organismal Cell-cell Adhesion Regulation Of Cell Migration Regulation Of Cell Motility Gastrulation Heterotypic Cell-cell Adhesion Regulation Of Locomotion Generation Of Neurons Regulation Of Cellular Component Movement Cellular Extravasation Positive Regulation Of Phosphatase Activity
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	abundance affects ancient associates conjugating connection cue dislocation droplet droplets endoplasmic engagement facilitates hrd1 impairs involves lipid localizes misfolded physically polyubiquitylation proteasome quality recruit reticulum sel1l ube2g2 ubiquitin ubiquitous
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	abundance affects ancient associates conjugating connection cue dislocation droplet droplets endoplasmic engagement facilitates hrd1 impairs involves lipid localizes misfolded physically polyubiquitylation proteasome quality recruit reticulum sel1l ube2g2 ubiquitin ubiquitous
Tagcloud (Intersection) ?