ITGAM and FGG

Number of citations of the paper that reports this interaction (PMID 9712878)
23

Data Source:
HPRD (in vivo)

		ITGAM	FGG
Gene Name		integrin, alpha M (complement component 3 receptor 3 subunit)	fibrinogen gamma chain
Image
Gene Ontology Annotations	Cellular Component	Nucleus Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Extracellular Vesicular Exosome	Extracellular Region Fibrinogen Complex Extracellular Space Plasma Membrane Cell Cortex External Side Of Plasma Membrane Cell Surface Platelet Alpha Granule Platelet Alpha Granule Lumen Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Opsonin Binding Glycoprotein Binding Protein Binding Heparin Binding Heparan Sulfate Proteoglycan Binding Metal Ion Binding Protein Heterodimerization Activity	Receptor Binding Structural Molecule Activity Protein Binding, Bridging Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Toll-like Receptor Signaling Pathway Leukocyte Migration Involved In Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Ectodermal Cell Differentiation Microglia Development Extracellular Matrix Organization Neutrophil Chemotaxis Toll-like Receptor 4 Signaling Pathway Innate Immune Response Cellular Extravasation Activated T Cell Proliferation Leukocyte Migration	Platelet Degranulation Cell-matrix Adhesion Signal Transduction Blood Coagulation Platelet Activation Extracellular Matrix Organization Positive Regulation Of Heterotypic Cell-cell Adhesion Cellular Protein Complex Assembly Positive Regulation Of Vasoconstriction Positive Regulation Of Exocytosis Positive Regulation Of Protein Secretion Protein Polymerization Response To Calcium Ion Positive Regulation Of ERK1 And ERK2 Cascade Platelet Aggregation Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Toll-Like Receptors Cascades Toll Like Receptor 4 (TLR4) Cascade Integrin cell surface interactions Cell surface interactions at the vascular wall Innate Immune System	p130Cas linkage to MAPK signaling for integrins Integrin alphaIIb beta3 signaling GRB2:SOS provides linkage to MAPK signaling for Integrins Platelet degranulation Platelet Aggregation (Plug Formation) Formation of Fibrin Clot (Clotting Cascade) Common Pathway Response to elevated platelet cytosolic Ca2+ Integrin cell surface interactions Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204446 23273568 18204098 21408207 19165918) Systemic lupus erythematosus and Systemic sclerosis ( 23740937)	D-dimer levels ( 21502573) Fibrinogen ( 20031577 21757653) Venous thromboembolism ( 21980494 23650146)
Protein-Protein Interactions		18 interactors: AUP1 C3 CD209 CFH CLEC4M ELANE FGG GP1BA HP ICAM1 ICAM2 ICAM4 IRAK1 ITGB2 JAM3 PLAUR SHARPIN THY1	10 interactors: F13A1 F13B FGA FGB ICAM1 ITGAM ITGB3 SERPINA5 VKORC1 VTN
Entrez ID		3684	2266
HPRD ID		00411	00621
Ensembl ID		ENSG00000169896	ENSG00000171557
Uniprot IDs		P11215	P02679
PDB IDs		1A8X 1BHO 1BHQ 1IDN 1IDO 1JLM 1M1U 1MF7 1N9Z 1NA5 2LKE 2LKJ 3Q3G 3QA3 4M76	1DUG 1FIB 1FIC 1FID 1FZA 1FZB 1FZC 1FZE 1FZF 1FZG 1LT9 1LTJ 1N86 1N8E 1RE3 1RE4 1RF0 1RF1 2A45 2FFD 2FIB 2H43 2HLO 2HOD 2HPC 2HWL 2OYH 2OYI 2Q9I 2VDO 2VDP 2VDQ 2VDR 2VR3 2XNX 2XNY 2Y7L 2Z4E 3BVH 3E1I 3FIB 3GHG 3H32 3HUS
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Regulation Of Immune System Process Cell Adhesion Regulation Of Immune Response Extracellular Matrix Organization Extracellular Structure Organization Defense Response Virion Attachment To Host Cell Response To Stress Immune System Process Adhesion Of Symbiont To Host Immune Response Inflammatory Response Innate Immune Response Peptide Antigen Transport Positive Regulation Of Immune System Process Positive Regulation Of Immune Response Cell-matrix Adhesion Blood Coagulation Hemostasis Cell-substrate Adhesion Leukocyte Migration Regulation Of Phosphorylation Acute Inflammatory Response To Antigenic Stimulus Acute Inflammatory Response Leukocyte Migration Involved In Inflammatory Response Complement Activation, Alternative Pathway Regulation Of Inflammatory Response Regulation Of Phosphorus Metabolic Process Regulation Of Body Fluid Levels Wound Healing Regulation Of Blood Coagulation Interaction With Host Regulation Of Protein Metabolic Process Leukocyte Cell-cell Adhesion Regulation Of Protein Phosphorylation Response To Stimulus Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Wounding Regulation Of Wound Healing Modulation By Virus Of Host Morphology Or Physiology Negative Regulation Of Endothelial Cell Apoptotic Process Viral Genome Replication Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Signal Transduction Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intracellular Transport Of Virus Positive Regulation Of Intracellular Signal Transduction Fibrinolysis Protein Activation Cascade	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Extracellular Matrix Organization Extracellular Structure Organization Response To Stress Platelet Degranulation Cell Activation Homotypic Cell-cell Adhesion Negative Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Vasoconstriction Regulation Of Endothelial Cell Apoptotic Process Platelet Aggregation Cell-matrix Adhesion Platelet Activation Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Single Organismal Cell-cell Adhesion Cell-substrate Adhesion Regulation Of Vasoconstriction Cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Exocytosis Innate Immune Response Cell Adhesion Mediated By Integrin Positive Regulation Of Phosphorylation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Secretion By Cell Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Regulation Of ERK1 And ERK2 Cascade Regulation Of Cell-substrate Adhesion Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Immune System Process Secretion Immune Response Leukocyte Migration Regulation Of Phosphorylation Defense Response
Tagcloud ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate
Tagcloud (Difference) ?		13qter 9p acp5 cckbr cholecystokinin chro chromosomes converter eleven ends fall39 glycoprotein integrin itgbeta2 linkage mapping mu opioid oprm1 pc1 pellucida rbp3 retinol rflp rnr1 ssc swine zona zp1	apo appeared approximately chain comparative conduct de differentially disappear exist expressions fibrinogen fragmented full h4 heavy inter iti iv kda lc matched pd people proteomic size spots trypsin validate
Tagcloud (Intersection) ?