ICAM1 and IL2RA

Number of citations of the paper that reports this interaction (PMID 1976256)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		ICAM1	IL2RA
Gene Name		intercellular adhesion molecule 1	interleukin 2 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Immunological Synapse Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Extracellular Vesicular Exosome	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Virus Receptor Activity Receptor Activity Transmembrane Signaling Receptor Activity Integrin Binding Protein Binding	Interleukin-2 Receptor Activity Drug Binding Interleukin-2 Binding
	Biological Process	Ovarian Follicle Development Regulation Of Leukocyte Mediated Cytotoxicity Response To Amphetamine T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Acute Inflammatory Response To Antigenic Stimulus T Cell Antigen Processing And Presentation Positive Regulation Of Cellular Extravasation Cell Adhesion Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell Aging Sensory Perception Of Sound Regulation Of Cell Shape Response To Virus Response To Ionizing Radiation Response To Sulfur Dioxide Response To Organic Cyclic Compound Cytokine-mediated Signaling Pathway Membrane To Membrane Docking Regulation Of Cell Adhesion Extracellular Matrix Organization Positive Regulation Of Actin Filament Polymerization Cellular Response To Nutrient Levels Positive Regulation Of Rho GTPase Activity Cell Adhesion Mediated By Integrin Response To Gonadotropin Response To Drug Response To Amino Acid Adhesion Of Symbiont To Host Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Ethanol Positive Regulation Of Vasoconstriction Response To Copper Ion Receptor-mediated Virion Attachment To Host Cell Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Leukocyte Migration Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Establishment Of Endothelial Barrier Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Cellular Response To Alkaloid Cellular Response To Glucose Stimulus Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Hypoxia Establishment Of Sertoli Cell Barrier Regulation Of Ruffle Assembly Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Endothelial Cell Apoptotic Process	Inflammatory Response To Antigenic Stimulus Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Cell Proliferation Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Defense Response To Virus Negative Regulation Of Inflammatory Response Negative Regulation Of Immune Response
Pathways		Interferon gamma signaling Interferon Signaling Cytokine Signaling in Immune system Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Adaptive Immune System	Signaling by GPCR G-protein beta:gamma signalling Cytokine Signaling in Immune system Signaling by Interleukins GPCR downstream signaling Interleukin receptor SHC signaling G beta:gamma signalling through PI3Kgamma Interleukin receptor SHC signaling GPVI-mediated activation cascade Interleukin-2 signaling Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling
Drugs		Natalizumab Hyaluronan	Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Soluble ICAM-1 ( 21533024 18604267)	Alopecia areata ( 20596022) Asthma (bronchodilator response) ( 23508266) Crohn's disease ( 21102463) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 22190364 19525953 19525955 17660530 21833088) Rheumatoid arthritis ( 20453842) Type 1 diabetes ( 19430480 22293688 18978792) Type 1 diabetes autoantibodies ( 21829393) Vitiligo ( 20410501)
Protein-Protein Interactions		12 interactors: EGFR EZR FGG HSD3B7 IL2RA IL2RG ITGAL ITGAM ITGB2 MSN SLC3A2 SPN	8 interactors: CD4 ICAM1 IL2 IL2RB NFKB1 SNTA1 STAT3 STAT5B
Entrez ID		3383	3559
HPRD ID		00996	00986
Ensembl ID		ENSG00000090339	ENSG00000134460
Uniprot IDs		B4DQW5 E7ESS4 P05362	P01589 Q5W005
PDB IDs		1D3E 1D3I 1D3L 1IAM 1IC1 1IJ4 1MQ8 1P53 1Z7Z 2OZ4 3TCX	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP
Enriched GO Terms of Interacting Partners?		Single Organismal Cell-cell Adhesion Leukocyte Migration Leukocyte Cell-cell Adhesion Cell Adhesion Locomotion Blood Coagulation Hemostasis Cell Migration Cell Motility Immune System Process Movement Of Cell Or Subcellular Component Activated T Cell Proliferation Regulation Of Body Fluid Levels Wound Healing Homotypic Cell-cell Adhesion Cell Activation Response To Wounding Immune Response Regulation Of Immune System Process Interleukin-2-mediated Signaling Pathway Regulation Of Immune Response Membrane To Membrane Docking T Cell Proliferation Positive Regulation Of Cell-cell Adhesion Chemotaxis T Cell Aggregation T Cell Activation Lymphocyte Aggregation Positive Regulation Of T Cell Proliferation Leukocyte Aggregation Response To Interleukin-2 Leukocyte Migration Involved In Inflammatory Response Cell Proliferation Lymphocyte Proliferation Defense Response Mononuclear Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation Integrin-mediated Signaling Pathway Leukocyte Proliferation Extracellular Matrix Organization Regulation Of Cell-cell Adhesion Extracellular Structure Organization Positive Regulation Of Cell Adhesion Lymphocyte Activation Inflammatory Response Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Response To Stress Cellular Extravasation	Negative Regulation Of Cell Death Cellular Response To Cytokine Stimulus Response To Cytokine T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Acute Inflammatory Response Regulation Of Cell Death Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Positive Regulation Of Cellular Biosynthetic Process Regulation Of Immune Response Positive Regulation Of Cytokine Production Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Interleukin-2 Negative Regulation Of Programmed Cell Death Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cytokine Biosynthetic Process Cell Surface Receptor Signaling Pathway Lymphocyte Activation Inflammatory Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-2 Biosynthetic Process Cellular Response To Organonitrogen Compound Response To Bacterium Response To Ethanol Leukocyte Activation Regulation Of Cellular Ketone Metabolic Process T Cell Differentiation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Protein Metabolic Process Single Organismal Cell-cell Adhesion Regulation Of Cytokine Production Viral Process JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Positive Regulation Of Signal Transduction Response To Copper Ion Positive Regulation Of Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Interleukin-2 Biosynthetic Process Growth Hormone Receptor Signaling Pathway Defense Response Cellular Response To Growth Hormone Stimulus Regulation Of Cell Adhesion Cellular Response To Interleukin-6 Positive Regulation Of Immune Response Positive Regulation Of T Cell Activation Regulation Of Peptidyl-tyrosine Phosphorylation
Tagcloud ?		baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3	artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		baboons barr carboxy cd30 cercopithicine divergence ebv epidemiologic epstein herpesvirus hodgkin homologs immortalization infecting latent lmp1 lmp1s lymphotropic monkeys naturally nonhuman papio primates pxqxt retain rhesus simian striking traf3	artp calculating chief convergence dusp2 hrgg il6 il8ra il8rb infgr1 irf2 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?