IREB2 and TERT

Number of citations of the paper that reports this interaction (PMID 23741361)
0

Data Source:
BioGRID (two hybrid)

		IREB2	TERT
Gene Name		iron-responsive element binding protein 2	telomerase reverse transcriptase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex
	Molecular Function	RNA Binding Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Aging Post-embryonic Development Response To Iron(II) Ion Negative Regulation Of Translation Osteoclast Differentiation Response To Retinoic Acid Erythrocyte Homeostasis Intestinal Absorption Cellular Response To Hypoxia	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838 20173748) Obesity-related traits ( 23251661)	Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		5 interactors: APP RBCK1 TERT USP53 YBX1	51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ
Entrez ID		3658	7015
HPRD ID		08858	01754
Ensembl ID		ENSG00000136381	ENSG00000164362
Uniprot IDs		D3DW85 P48200	O14746
PDB IDs			2BCK 4B18
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression RNA Processing Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Protein Linear Polyubiquitination Telomere Formation Via Telomerase Regulation Of Extrinsic Apoptotic Signaling Pathway Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition CRD-mediated MRNA Stabilization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Telomere Assembly Neuron Remodeling Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Positive Regulation Of Gene Expression Negative Regulation Of Necroptotic Process MRNA Processing RNA Interference Negative Regulation Of Necrotic Cell Death Replicative Senescence Regulation Of Necroptotic Process Cellular Copper Ion Homeostasis Negative Regulation Of Striated Muscle Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process RNA-dependent DNA Replication Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Regulation Of Necrotic Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Cellular Protein Catabolic Process MRNA Stabilization Negative Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Catabolic Process	Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway
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Tagcloud (Difference) ?			5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine
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