IREB2 and USP53

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		IREB2	USP53
Gene Name		iron-responsive element binding protein 2	ubiquitin specific peptidase 53
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cellular_component
	Molecular Function	RNA Binding Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Aging Post-embryonic Development Response To Iron(II) Ion Negative Regulation Of Translation Osteoclast Differentiation Response To Retinoic Acid Erythrocyte Homeostasis Intestinal Absorption Cellular Response To Hypoxia	Ubiquitin-dependent Protein Catabolic Process Biological_process
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838 20173748) Obesity-related traits ( 23251661)
Protein-Protein Interactions		5 interactors: APP RBCK1 TERT USP53 YBX1	5 interactors: DAB1 GRB2 IREB2 PVRL2 TRAF2
Entrez ID		3658	54532
HPRD ID		08858	11669
Ensembl ID		ENSG00000136381	ENSG00000145390
Uniprot IDs		D3DW85 P48200	Q70EK8 Q9H9I0
PDB IDs
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression RNA Processing Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Protein Linear Polyubiquitination Telomere Formation Via Telomerase Regulation Of Extrinsic Apoptotic Signaling Pathway Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition CRD-mediated MRNA Stabilization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Telomere Assembly Neuron Remodeling Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Positive Regulation Of Gene Expression Negative Regulation Of Necroptotic Process MRNA Processing RNA Interference Negative Regulation Of Necrotic Cell Death Replicative Senescence Regulation Of Necroptotic Process Cellular Copper Ion Homeostasis Negative Regulation Of Striated Muscle Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process RNA-dependent DNA Replication Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Regulation Of Necrotic Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Cellular Protein Catabolic Process MRNA Stabilization Negative Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Catabolic Process	Positive Regulation Of Cell Activation Regulation Of Cell Activation Regulation Of Cell Adhesion Positive Regulation Of Immune Response Positive Regulation Of T Cell Mediated Immunity Cell-cell Adhesion Involved In Neuronal-glial Interactions Involved In Cerebral Cortex Radial Glia Guided Migration Coreceptor-mediated Virion Attachment To Host Cell Protein Heterooligomerization Positive Regulation Of Adaptive Immune Response Susceptibility To T Cell Mediated Cytotoxicity Sperm Mitochondrion Organization Cerebellum Structural Organization Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Lateral Motor Column Neuron Migration Fusion Of Virus Membrane With Host Plasma Membrane Regulation Of Adaptive Immune Response Positive Regulation Of T Cell Activation Spinal Cord Motor Neuron Migration Positive Regulation Of Homotypic Cell-cell Adhesion Radial Glia Guided Migration Of Purkinje Cell Response To Iron(II) Ion Susceptibility To Natural Killer Cell Mediated Cytotoxicity Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Positive Regulation Of Cell-cell Adhesion Regulation Of Innate Immune Response Cell Projection Organization Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target Negative Regulation Of Glial Cell Apoptotic Process Locomotion Regulation Of T Cell Activation Regulation Of Immune System Process Regulation Of Phosphorylation Virion Attachment To Host Cell Positive Regulation Of Immune Response To Tumor Cell Protoporphyrinogen IX Biosynthetic Process Cellular Response To Stimulus Aging Adhesion Of Symbiont To Host Cell Differentiation Positive Regulation Of Protein Homodimerization Activity Branching Involved In Labyrinthine Layer Morphogenesis Regulation Of Phosphorus Metabolic Process Cellular Response To Nitric Oxide Protoporphyrinogen IX Metabolic Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Cellular Response To Stress
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