IREB2

Gene Name		iron-responsive element binding protein 2
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol
	Molecular Function	RNA Binding Protein Binding Iron-responsive Element Binding Translation Repressor Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Iron Ion Transport Cellular Iron Ion Homeostasis Aging Post-embryonic Development Response To Iron(II) Ion Negative Regulation Of Translation Osteoclast Differentiation Response To Retinoic Acid Erythrocyte Homeostasis Intestinal Absorption Cellular Response To Hypoxia
Pathways
Drugs
Diseases
GWAS		Chronic obstructive pulmonary disease ( 22080838 20173748) Obesity-related traits ( 23251661)
Protein-protein Interactions		5 interactors: APP RBCK1 TERT USP53 YBX1
Entrez ID		3658
HPRD ID		08858
Ensembl ID		ENSG00000136381
Uniprot IDs		D3DW85 P48200
PDB IDs
Enriched GO Terms of Interacting Partners?		Posttranscriptional Regulation Of Gene Expression RNA Processing Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Age-dependent Telomere Shortening Protein Linear Polyubiquitination Telomere Formation Via Telomerase Regulation Of Extrinsic Apoptotic Signaling Pathway Telomere Maintenance Via Telomere Shortening Collateral Sprouting Axon Midline Choice Point Recognition CRD-mediated MRNA Stabilization Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Telomere Assembly Neuron Remodeling Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Positive Regulation Of Gene Expression Negative Regulation Of Necroptotic Process MRNA Processing RNA Interference Negative Regulation Of Necrotic Cell Death Replicative Senescence Regulation Of Necroptotic Process Cellular Copper Ion Homeostasis Negative Regulation Of Striated Muscle Cell Differentiation Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process RNA-dependent DNA Replication Positive Regulation Of NF-kappaB Import Into Nucleus Regulation Of Gene Silencing Copper Ion Homeostasis Suckling Behavior MRNA Metabolic Process Regulation Of Necrotic Cell Death Proteolysis Involved In Cellular Protein Catabolic Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Cellular Protein Catabolic Process MRNA Stabilization Negative Regulation Of Cellular Metabolic Process Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Catabolic Process
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