TERT and SMG6

Number of citations of the paper that reports this interaction (PMID 12699629)
49

Data Source:
HPRD (in vitro, in vivo)

		TERT	SMG6
Gene Name		telomerase reverse transcriptase	SMG6 nonsense mediated mRNA decay factor
Image
Gene Ontology Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Chromosome, Telomeric Region Nucleus Telomerase Holoenzyme Complex Nucleolus Cytoplasm Cytosol Exon-exon Junction Complex
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding	Endoribonuclease Activity Protein Binding Telomeric DNA Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Telomere Maintenance MRNA Export From Nucleus Gene Expression Regulation Of Dephosphorylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic
Pathways		Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Nonsense-Mediated Decay (NMD) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)	Aortic root size ( 19584346) Bone mineral density ( 22504420) Coronary heart disease ( 21378990) Esophageal cancer (squamous cell) ( 22960999) Metabolite levels (5-HIAA) ( 23319000)
Protein-Protein Interactions		51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	3 interactors: PPP1CC SMG5 TERT
Entrez ID		7015	23293
HPRD ID		01754	06502
Ensembl ID		ENSG00000164362	ENSG00000070366
Uniprot IDs		O14746	Q86US8
PDB IDs		2BCK 4B18	2DOK 2HWW 2HWX
Enriched GO Terms of Interacting Partners?		Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway	Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of RNA Interference Transcription, RNA-templated Telomere Formation Via Telomerase Age-dependent Telomere Shortening Telomere Maintenance Via Telomere Shortening Telomere Assembly Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference RNA Interference Replicative Senescence Triglyceride Catabolic Process RNA-dependent DNA Replication Regulation Of Gene Silencing Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Acylglycerol Catabolic Process DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Cellular Response To DsRNA Posttranscriptional Gene Silencing Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Glycogen Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing By RNA MRNA Export From Nucleus Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Cell Aging Response To DsRNA RNA Export From Nucleus Telomere Maintenance Circadian Regulation Of Gene Expression Polysaccharide Metabolic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Triglyceride Metabolic Process Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Regulation Of Circadian Rhythm Gene Silencing Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Neutral Lipid Metabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus DNA Biosynthetic Process Nuclear Export MRNA Transport Regulation Of Dephosphorylation Catabolic Process
Tagcloud ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms
Tagcloud (Difference) ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	atf atf6 caenorhabditis counteracts elegans exos exosome f48e8 folding fundamental ire ire1 larval lethality maintains metazoans misfolded neurologic nmd nonsense ok275 pek sensitize tm1153 transducers upr v33 worms
Tagcloud (Intersection) ?