TERT and DYNLL1

Number of citations of the paper that reports this interaction (PMID 23741361)
0

Data Source:
BioGRID (two hybrid)

		TERT	DYNLL1
Gene Name		telomerase reverse transcriptase	dynein, light chain, LC8-type 1
Image
Gene Ontology Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Kinetochore Nucleus Cytoplasm Mitochondrion Centrosome Cytosol Cytoplasmic Dynein Complex Microtubule Plasma Membrane COP9 Signalosome Membrane Extracellular Vesicular Exosome Primary Cilium Mitotic Spindle Ciliary Tip
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding	Motor Activity Protein Binding Protein C-terminus Binding Enzyme Binding Protein Domain Specific Binding Nitric-oxide Synthase Regulator Activity Protein Homodimerization Activity
	Biological Process	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Transcription, DNA-templated Regulation Of Transcription, DNA-templated Transport Apoptotic Process Organelle Organization Microtubule-based Process Female Gamete Generation Anatomical Structure Morphogenesis Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Substantia Nigra Development Actin Cytoskeleton Organization Negative Regulation Of Phosphorylation Regulation Of Catalytic Activity Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway
Pathways		Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Organelle biogenesis and maintenance Activation of BH3-only proteins Assembly of the primary cilium G2/M Transition Anchoring of the basal body to the plasma membrane Regulation of PLK1 Activity at G2/M Transition Cell Cycle, Mitotic Intraflagellar transport Loss of proteins required for interphase microtubule organizationÂ from the centrosome Activation of BIM and translocation to mitochondria Loss of Nlp from mitotic centrosomes MHC class II antigen presentation Programmed Cell Death Centrosome maturation Mitotic G2-G2/M phases Recruitment of mitotic centrosome proteins and complexes Adaptive Immune System Intrinsic Pathway for Apoptosis
Drugs
Diseases
GWAS		Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	77 interactors: ACTB ACTC1 ACTG1 ALDOA AMBRA1 AMOTL2 B3GALT4 BCAS1 BCL2L11 BMF C14orf1 CA2 CACNB1 CCDC36 CLIP2 CS DAZ1 DLG4 DLGAP1 DNAJB9 DNM2 DNM3 DNMT1 DYNC1H1 DYNC1I1 EEF1A1 GAPDH GLUD1 GLUL GNB2L1 GPHN GRIN3A HIP1R HSPA8 INPP1 IQUB KANK2 LDHA MAP1B MARK3 MAST2 ME2 MTA1 MTR MYO10 MYO5A NDUFA4L2 NFKBIA NOS1 NRF1 NTRK1 NTRK2 NTRK3 PAK1 PAN2 PARD3 PAX6 PFKM PFKP PKIA PKIB PKIG POLH RAB4A RGS2 SHROOM3 TERT THAP8 TNFRSF14 TP53BP1 TUBA3C TUBB TXNDC17 VIM ZHX1 ZMYND11 ZNF354A
Entrez ID		7015	8655
HPRD ID		01754	03334
Ensembl ID		ENSG00000164362	ENSG00000088986
Uniprot IDs		O14746	P63167 Q6FGH9
PDB IDs		2BCK 4B18	1CMI 3ZKE 3ZKF
Enriched GO Terms of Interacting Partners?		Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway	Nervous System Development Movement Of Cell Or Subcellular Component Cell Differentiation Developmental Process Regulation Of Cellular Component Organization Response To Organic Substance Regulation Of Cellular Localization Neuron Projection Morphogenesis Axonogenesis Cellular Response To Stimulus Synapse Organization Neuron Projection Development Neuron Development Regulation Of Cellular Protein Metabolic Process Response To Stimulus Neuron Differentiation Regulation Of Protein Metabolic Process Axon Development Cell Projection Morphogenesis Response To External Stimulus Anatomical Structure Morphogenesis Cell Projection Organization Cell Morphogenesis Involved In Neuron Differentiation Cell Part Morphogenesis Cellular Process Negative Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Protein Homooligomerization Cell Morphogenesis Axon Guidance Negative Regulation Of Phosphorylation Regulation Of Cellular Process Glycolytic Process Locomotion Cell Development Negative Regulation Of Protein Phosphorylation Cytoskeleton Organization Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Membrane Organization Regulation Of CAMP-dependent Protein Kinase Activity Cell Morphogenesis Involved In Differentiation Anatomical Structure Development Generation Of Neurons System Development Response To Stress Regulation Of Protein Phosphorylation Multicellular Organismal Development Neuromuscular Junction Development Pyruvate Metabolic Process Actin Filament-based Process
Tagcloud ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
Tagcloud (Difference) ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	1inq53a 250viqd 52gqvd adapter attempt capsid defective dynein hiv immunodeficiency integrase interaction kd ma motifs mutational p150glued particulate predicts proper q252a replication requirement reverse steps tctex transcriptase uncoating
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