TERT and TGFBR2

Number of citations of the paper that reports this interaction (PMID 23741361)
0

Data Source:
BioGRID (two hybrid)

		TERT	TGFBR2
Gene Name		telomerase reverse transcriptase	transforming growth factor, beta receptor II (70/80kDa)
Image
Gene Ontology Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Cytosol Plasma Membrane Caveola External Side Of Plasma Membrane Integral Component Of Membrane Receptor Complex Transforming Growth Factor Beta Receptor Homodimeric Complex
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding	Transmembrane Receptor Protein Serine/threonine Kinase Activity Receptor Signaling Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Transforming Growth Factor Beta Receptor Activity, Type II Protein Binding ATP Binding Glycosaminoglycan Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Type I Transforming Growth Factor Beta Receptor Binding Type III Transforming Growth Factor Beta Receptor Binding SMAD Binding Metal Ion Binding Transforming Growth Factor Beta Binding
	Biological Process	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Blood Vessel Development Patterning Of Blood Vessels Vasculogenesis In Utero Embryonic Development Positive Regulation Of Mesenchymal Cell Proliferation Lens Development In Camera-type Eye Positive Regulation Of Tolerance Induction To Self Antigen Positive Regulation Of B Cell Tolerance Induction Positive Regulation Of T Cell Tolerance Induction Growth Plate Cartilage Chondrocyte Growth Protein Phosphorylation Receptor-mediated Endocytosis Apoptotic Process Transforming Growth Factor Beta Receptor Signaling Pathway Common-partner SMAD Protein Phosphorylation Smoothened Signaling Pathway Gastrulation Brain Development Heart Development Embryo Implantation Aging Response To Nutrient Positive Regulation Of Cell Proliferation Response To Mechanical Stimulus Response To Glucose Regulation Of Gene Expression Positive Regulation Of Epithelial Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Phosphorylation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Organ Regeneration Activation Of Protein Kinase Activity Embryonic Hemopoiesis Wound Healing Regulation Of Cell Proliferation Response To Drug Myeloid Dendritic Cell Differentiation Positive Regulation Of Skeletal Muscle Tissue Regeneration Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Smooth Muscle Cell Proliferation Embryonic Cranial Skeleton Morphogenesis Positive Regulation Of NK T Cell Differentiation Palate Development Negative Regulation Of Cardiac Muscle Cell Proliferation Pathway-restricted SMAD Protein Phosphorylation Bronchus Morphogenesis Trachea Formation Mammary Gland Morphogenesis Lung Lobe Morphogenesis Response To Cholesterol Lens Fiber Cell Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Loss of Function of TGFBR2 in Cancer TGFBR2 MSI Frameshift Mutants in Cancer TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) SMAD2/3 Phosphorylation Motif Mutants in Cancer Loss of Function of SMAD2/3 in Cancer TGFBR2 Kinase Domain Mutants in Cancer Downregulation of TGF-beta receptor signaling SMAD2/3 MH2 Domain Mutants in Cancer Loss of Function of SMAD4 in Cancer TGFBR1 KD Mutants in Cancer TGF-beta receptor signaling activates SMADs TGFBR1 LBD Mutants in Cancer Loss of Function of TGFBR1 in Cancer Signaling by TGF-beta Receptor Complex in Cancer Signaling by TGF-beta Receptor Complex SMAD4 MH2 Domain Mutants in Cancer
Drugs			Glycerol
Diseases
GWAS		Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)	Breast cancer ( 23535729) Migraine ( 22683712) Tonometry ( 17903302)
Protein-Protein Interactions		51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	44 interactors: ACVR1 ACVRL1 AP2B1 APP ARHGEF6 ARHGEF7 CBL CCNB1 CCNB2 CD44 CDK1 CLU CTNNB1 DAB2 DAXX EIF3I ENG GOPC KCNK18 NRP1 OSR1 PAK1 PDGFRA PIK3R1 PIK3R2 PML RCVRN SMAD3 SMAD4 SMAD7 SNX6 STRAP TCTEX1D4 TERT TGFB1 TGFB1I1 TGFB2 TGFB3 TGFBR1 TGFBR3 TGFBRAP1 TRAP1 TSSK1B ZFYVE9
Entrez ID		7015	7048
HPRD ID		01754	01823
Ensembl ID		ENSG00000164362	ENSG00000163513
Uniprot IDs		O14746	A3QNQ0 D2JYI1 P37173
PDB IDs		2BCK 4B18	1KTZ 1M9Z 1PLO 2PJY 3KFD
Enriched GO Terms of Interacting Partners?		Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway	Cellular Response To Growth Factor Stimulus Response To Growth Factor Enzyme Linked Receptor Protein Signaling Pathway Cellular Response To Transforming Growth Factor Beta Stimulus Transforming Growth Factor Beta Receptor Signaling Pathway Response To Transforming Growth Factor Beta Regulation Of Signal Transduction Cellular Response To Organic Substance Regulation Of Signaling Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Regulation Of Phosphorus Metabolic Process Regulation Of Phosphorylation Regulation Of Epithelial To Mesenchymal Transition Response To Organic Substance Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Protein Phosphorylation Positive Regulation Of Signal Transduction Regulation Of Cellular Response To Growth Factor Stimulus Cell Surface Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Cellular Metabolic Process Regulation Of Catalytic Activity Regulation Of Metabolic Process Regulation Of Protein Metabolic Process Tube Development Response To Wounding Regulation Of Cell Death Signaling Positive Regulation Of Phosphorylation Regulation Of Cell Differentiation Cellular Response To Stimulus Signal Transduction Cell Communication Response To Stress Regulation Of Gene Expression Regulation Of Apoptotic Process Tissue Morphogenesis Anatomical Structure Morphogenesis
Tagcloud ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
Tagcloud (Difference) ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	aaa adventitial alleles aneurysm aortas aortic betatype disruption elastase elastin fourteen genetical infiltration infrarenal medial metalloproteinases myhcre peri principal prominently resident sm smc smooth transforming wise
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