TERT and SLC7A11

Number of citations of the paper that reports this interaction (PMID 23741361)
0

Data Source:
BioGRID (two hybrid)

		TERT	SLC7A11
Gene Name		telomerase reverse transcriptase	solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Telomerase Catalytic Core Complex Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nucleoplasm Telomerase Holoenzyme Complex Nucleolus PML Body RNA-directed RNA Polymerase Complex Mitochondrial Nucleoid TERT-RMRP Complex	Rough Endoplasmic Reticulum Cytoskeleton Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	TRNA Binding Transcription Coactivator Binding DNA Binding Telomerase Activity Telomeric Template RNA Reverse Transcriptase Activity RNA-directed RNA Polymerase Activity Protein Binding Nucleotidyltransferase Activity Telomeric DNA Binding Protein Homodimerization Activity Metal Ion Binding Telomeric RNA Binding	Protein Binding Cystine:glutamate Antiporter Activity
	Biological Process	Telomere Maintenance Transcription, RNA-templated Age-dependent Telomere Shortening Telomere Maintenance Via Telomerase Mitochondrion Organization DNA Strand Elongation Positive Regulation Of Wnt Signaling Pathway Production Of SiRNA Involved In RNA Interference Telomere Formation Via Telomerase Replicative Senescence Negative Regulation Of Production Of SiRNA Involved In RNA Interference Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ion Transport Amino Acid Transport Response To Oxidative Stress Brain Development Blood Coagulation Response To Toxic Substance Response To Nicotine Leukocyte Migration Transmembrane Transport Lens Fiber Cell Differentiation Platelet Aggregation L-glutamate Transmembrane Transport
Pathways		Telomere Maintenance Chromosome Maintenance misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling TCF dependent signaling in response to WNT RNF mutants show enhanced WNT signaling and proliferation formation of the beta-catenin:TCF transactivating complex Extension of Telomeres Telomere Extension By Telomerase XAV939 inhibits tankyrase, stabilizing AXIN Signaling by Wnt Signaling by WNT in cancer	Transport of inorganic cations/anions and amino acids/oligopeptides Amino acid transport across the plasma membrane SLC-mediated transmembrane transport Basigin interactions Cell surface interactions at the vascular wall
Drugs			L-Cystine L-Glutamic Acid Riluzole Sulfasalazine
Diseases
GWAS		Bladder cancer ( 20972438) Breast cancer ( 22037553 23535729 23535733) Glioma ( 21827660 21531791 22886559 19578367) Idiopathic pulmonary fibrosis ( 18835860) Interstitial lung disease ( 23583980) Lung adenocarcinoma ( 20700438 19836008 22797724 20871597) Lung cancer ( 21725308 23143601 18978790) Melanoma ( 21983787) Prostate cancer ( 21743467) Prostate-specific antigen levels ( 21160077) Red blood cell count ( 20139978) Testicular germ cell cancer ( 20543847) Testicular germ cell tumor ( 23666240)
Protein-Protein Interactions		51 interactors: ABL1 ACAA2 AKT1 ANXA2 ATP5B C19orf40 CCT5 CIB1 DDX51 DYNLL1 DYRK2 EIF2S1 ENO1 GLA HSP90AA1 HSPA4 IREB2 MCRS1 MDM2 MTOR NCL PABPC1 PBK PFDN1 PHF20L1 PINX1 PPIA PRKCA PTGES3 RELA RPS6KB1 RUVBL1 RUVBL2 SERBP1 SLC7A11 SMG5 SMG6 SRC STEAP4 TEP1 TERF1 TGFBR2 TIMM21 TPP1 TUBA1B U2SURP XPO1 XRCC5 XRCC6 YWHAQ YWHAZ	3 interactors: BAAT SLC3A2 TERT
Entrez ID		7015	23657
HPRD ID		01754	09720
Ensembl ID		ENSG00000164362	ENSG00000151012
Uniprot IDs		O14746	Q9UPY5
PDB IDs		2BCK 4B18
Enriched GO Terms of Interacting Partners?		Organelle Organization Telomere Maintenance Cellular Response To Stress Response To Stress Response To Abiotic Stimulus Negative Regulation Of Cellular Metabolic Process Regulation Of Intracellular Transport DNA Metabolic Process Mitotic Cell Cycle Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization RNA-dependent DNA Replication Regulation Of Cellular Localization Positive Regulation Of Protein Metabolic Process Cellular Metabolic Process Regulation Of Metabolic Process Immune System Process Regulation Of Protein Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Response To Drug Regulation Of Protein Localization Regulation Of Cell Death Apoptotic Process Cell Cycle Response To Organic Substance Positive Regulation Of Organelle Organization Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Stimulus Mitotic Cell Cycle Process Programmed Cell Death Cell Death Death Regulation Of Apoptotic Process Cellular Response To Growth Factor Stimulus Regulation Of Cellular Protein Metabolic Process Response To Growth Factor Peptidyl-amino Acid Modification Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Hypoxia ERBB Signaling Pathway Cellular Response To Decreased Oxygen Levels Negative Regulation Of Cell Death Positive Regulation Of Cellular Metabolic Process Homeostatic Process Fc Receptor Signaling Pathway Cellular Response To Organic Substance Cellular Response To Oxygen Levels Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway	Response To DsRNA Leucine Import Bile Acid Conjugation Negative Regulation Of Production Of SiRNA Involved In RNA Interference Tryptophan Transport Negative Regulation Of RNA Interference Transcription, RNA-templated Telomere Formation Via Telomerase Age-dependent Telomere Shortening Aromatic Amino Acid Transport Telomere Maintenance Via Telomere Shortening Carboxylic Acid Transport Organic Acid Transport Leucine Transport Telomere Assembly Taurine Metabolic Process Organic Anion Transport Branched-chain Amino Acid Transport Replicative Cell Aging Telomere Maintenance Via Telomerase Production Of SiRNA Involved In RNA Interference Amino Acid Import RNA Interference Replicative Senescence Anion Transport RNA-dependent DNA Replication Bile Acid Biosynthetic Process Regulation Of Gene Silencing DNA Strand Elongation Telomere Maintenance Via Telomere Lengthening Bile Acid And Bile Salt Transport Response To Organic Cyclic Compound Glycine Metabolic Process Cellular Response To DsRNA Bile Acid Metabolic Process Posttranscriptional Gene Silencing Neutral Amino Acid Transport Response To Exogenous DsRNA Serine Family Amino Acid Metabolic Process Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing By RNA Acyl-CoA Metabolic Process Cell Aging Organ Regeneration Telomere Maintenance Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Gene Silencing Amino Acid Transmembrane Transport DNA Biosynthetic Process Steroid Biosynthetic Process
Tagcloud ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators nfe2l2 pn proneural psychoactive redox regrowth renewal reprogramming resist ros solute sox2 taqman therapeutics xc xct
Tagcloud (Difference) ?		5alpha butyl chlorinated cholestane coprostanol dihydrocholesterol epicoprostanol ether experiment extraction fid final gc internal involves limit liquid methanol method microg namely quantification recovery reextraction saponification silylation solvents sterols urine	adapt anionic cannabidiol cannabinoid cbd combinatorial endowed gbm gsc gscs id1 mes modulators nfe2l2 pn proneural psychoactive redox regrowth renewal reprogramming resist ros solute sox2 taqman therapeutics xc xct
Tagcloud (Intersection) ?