APOA2 and VKORC1

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		APOA2	VKORC1
Gene Name		apolipoprotein A-II	vitamin K epoxide reductase complex, subunit 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Early Endosome Endoplasmic Reticulum Lumen Cytosol Very-low-density Lipoprotein Particle High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Extracellular Vesicular Exosome Blood Microparticle	Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Lipid Transporter Activity Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Cholesterol Binding Cholesterol Transporter Activity Phosphatidylcholine Binding Apolipoprotein Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity Lipase Inhibitor Activity Phosphatidylcholine-sterol O-acyltransferase Activator Activity High-density Lipoprotein Particle Receptor Binding	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding
	Biological Process	Retinoid Metabolic Process Acute Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Protein Folding Triglyceride Metabolic Process Phosphatidylcholine Biosynthetic Process Phototransduction, Visible Light Cholesterol Metabolic Process Phospholipid Catabolic Process Response To Glucose Positive Regulation Of Cholesterol Esterification Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Viral Process Protein Oxidation Peptidyl-methionine Modification Regulation Of Intestinal Cholesterol Absorption Organ Regeneration Regulation Of Protein Stability Negative Regulation Of Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Triglyceride-rich Lipoprotein Particle Remodeling Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Assembly High-density Lipoprotein Particle Clearance Lipoprotein Metabolic Process Response To Drug Cholesterol Homeostasis Positive Regulation Of Catalytic Activity Response To Estrogen Reverse Cholesterol Transport Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Interleukin-8 Biosynthetic Process Diacylglycerol Catabolic Process Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Response To Glucocorticoid Negative Regulation Of Lipase Activity Negative Regulation Of Cholesterol Import Negative Regulation Of Cholesterol Transporter Activity	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development
Pathways		Lipoprotein metabolism PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism Visual phototransduction Metabolism of lipids and lipoproteins Chylomicron-mediated lipid transport Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Lipid digestion, mobilization, and transport Diseases associated with visual transduction Retinoid metabolism and transport	Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs			Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS			Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		11 interactors: ABCA13 APOA1 APOA1BP APOC1 APOD APOF C4A CATSPER1 PLTP SCARB1 VKORC1	80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB
Entrez ID		336	79001
HPRD ID		00129	10540
Ensembl ID		ENSG00000158874	ENSG00000167397
Uniprot IDs		P02652	Q9BQB6
PDB IDs		1L6L 2OU1
Enriched GO Terms of Interacting Partners?		Cholesterol Efflux Lipid Transport Lipid Localization Sterol Transport Cholesterol Transport High-density Lipoprotein Particle Remodeling Cholesterol Metabolic Process Plasma Lipoprotein Particle Remodeling Sterol Metabolic Process Plasma Lipoprotein Particle Clearance Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Regulation Of Lipid Catabolic Process High-density Lipoprotein Particle Clearance Regulation Of Plasma Lipoprotein Particle Levels Steroid Metabolic Process Positive Regulation Of Cholesterol Esterification Regulation Of Lipid Metabolic Process Lipid Metabolic Process Phospholipid Transport Regulation Of Cholesterol Esterification Peripheral Nervous System Axon Regeneration Phospholipid Efflux Alcohol Metabolic Process Small Molecule Metabolic Process Protein-lipid Complex Assembly Endothelial Cell Proliferation Regulation Of Lipid Biosynthetic Process Reverse Cholesterol Transport Negative Regulation Of Lipase Activity Lipoprotein Metabolic Process Positive Regulation Of Steroid Metabolic Process Regulation Of Endocytosis Blood Vessel Endothelial Cell Migration Regulation Of Fatty Acid Biosynthetic Process Regulation Of Triglyceride Metabolic Process Wound Healing Triglyceride Homeostasis Acylglycerol Homeostasis Regulation Of Cholesterol Transport Axon Regeneration Response To Wounding Neuron Projection Regeneration Regulation Of Inflammatory Response Sperm Motility Transport Positive Regulation Of Lipid Biosynthetic Process Regulation Of Phagocytosis Response To Axon Injury Negative Regulation Of Phosphatidylcholine Catabolic Process	Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport
Tagcloud ?		atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Difference) ?		atp1 craniorachischisis d1hun13 d1hun14 d1mit110 d1mit111 d1mit112 d1mit114 d1mit145 d1mit146 d1mit147 d1mit148 d1mit149 d1mit15 d1mit205 d1mit270 d1mit36 d1mit62 eph1 fcer1 fcgr2 hlix1 intergene interlocus looptail spna1 spretus sslp swr	arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd
Tagcloud (Intersection) ?