VKORC1 and HOMER2

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	HOMER2
Gene Name		vitamin K epoxide reductase complex, subunit 1	homer homolog 2 (Drosophila)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Nucleus Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell Junction Dendrite Neuronal Cell Body Apical Part Of Cell Postsynaptic Membrane Neuronal Postsynaptic Density
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Actin Binding Protein Domain Specific Binding GKAP/Homer Scaffold Activity G-protein Coupled Glutamate Receptor Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	G-protein Coupled Glutamate Receptor Signaling Pathway Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Calcium-mediated Signaling Using Intracellular Calcium Source Behavioral Response To Cocaine Chemical Homeostasis Within A Tissue Regulation Of Store-operated Calcium Entry
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	11 interactors: AGAP2 APP DBN1 GRM1 ITPR1 KPNA2 LZTS2 RNF41 RYR1 UBXN1 VKORC1
Entrez ID		79001	9455
HPRD ID		10540	07269
Ensembl ID		ENSG00000167397	ENSG00000103942
Uniprot IDs		Q9BQB6	Q9NSB8
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Positive Regulation Of Cytosolic Calcium Ion Concentration Cytosolic Calcium Ion Homeostasis Cellular Chemical Homeostasis Ion Homeostasis Endoplasmic Reticulum Calcium Ion Homeostasis Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Signaling Regulation Of Sequestering Of Calcium Ion Cytoplasmic Transport Calcium Ion Transport Into Cytosol Cellular Homeostasis Cytosolic Calcium Ion Transport Cellular Localization Intracellular Transport Glutamate Receptor Signaling Pathway Chemical Homeostasis Dimeric G-protein Coupled Receptor Signaling Pathway Regulation Of Signal Transduction Blood Coagulation Hemostasis Cell Communication Synaptic Growth At Neuromuscular Junction Response To Abiotic Stimulus Establishment Of Localization In Cell Cell Surface Receptor Signaling Pathway Negative Regulation Of Protein Catabolic Process Collateral Sprouting In Absence Of Injury Cell Communication By Chemical Coupling Response To Stimulus Voluntary Musculoskeletal Movement Multicellular Organismal Development Regulation Of Body Fluid Levels Regulation Of Phosphorylation Collateral Sprouting Axon Midline Choice Point Recognition Wound Healing Cellular Response To Stimulus Regulation Of Ion Homeostasis Homeostatic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Positive Regulation Of Mammary Gland Epithelial Cell Proliferation Vitamin K Metabolic Process Regulation Of Phosphorus Metabolic Process
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	accumbens activational addictive arguing aversion behaviorally blunt cci constriction cpa cpp heroin incentive intrathecal limbic mesolimbic mglur5 motivational neuroadaptations psychopharmacology uninjured
Tagcloud (Intersection) ?