VKORC1 and REEP5

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	REEP5
Gene Name		vitamin K epoxide reductase complex, subunit 1	receptor accessory protein 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Membrane Extracellular Vesicular Exosome
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Molecular_function Protein Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Biological_process
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)	Attention deficit hyperactivity disorder ( 18839057)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	7 interactors: ARFGAP1 GTF2H1 NUDT3 RAB5B RABAC1 RGS2 VKORC1
Entrez ID		79001	7905
HPRD ID		10540	15918
Ensembl ID		ENSG00000167397	ENSG00000129625
Uniprot IDs		Q9BQB6	B7Z681 Q00765
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Diphosphoinositol Polyphosphate Catabolic Process Diadenosine Polyphosphate Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Adrenergic Receptor Signaling Pathway Vitamin K Metabolic Process Positive Regulation Of Cardiac Muscle Contraction Regulation Of Protein Phosphorylation Negative Regulation Of CAMP-mediated Signaling Plasma Membrane To Endosome Transport Negative Regulation Of Phospholipase Activity Relaxation Of Vascular Smooth Muscle Relaxation Of Smooth Muscle Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Striated Muscle Contraction Negative Regulation Of Muscle Hypertrophy Regulation Of Phosphorylation COPI-coated Vesicle Budding COPI Coating Of Golgi Vesicle Positive Regulation Of Microtubule Polymerization Peptidyl-glutamic Acid Carboxylation Relaxation Of Cardiac Muscle Golgi Vesicle Budding Negative Regulation Of Smooth Muscle Contraction Regulation Of Phosphorus Metabolic Process Nucleotide-excision Repair, DNA Damage Removal Aromatic Compound Catabolic Process Negative Regulation Of Lipase Activity Negative Regulation Of Muscle Contraction Regulation Of CAMP-mediated Signaling Relaxation Of Muscle Termination Of RNA Polymerase I Transcription Transcription Elongation From RNA Polymerase I Promoter Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Heart Contraction Regulation Of Microtubule Polymerization Vesicle Targeting, To, From Or Within Golgi Endosome Organization Regulation Of Cardiac Muscle Hypertrophy 7-methylguanosine MRNA Capping Transcription From RNA Polymerase I Promoter Vasodilation 7-methylguanosine RNA Capping Regulation Of Cellular Protein Metabolic Process Retrograde Vesicle-mediated Transport, Golgi To ER Quinone Metabolic Process Drug Metabolic Process Transcription-coupled Nucleotide-excision Repair Localization Within Membrane Vesicle Targeting
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes searched sought srp19 surrounding taqman transformed variation volunteers yielded
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	5q22 adjusted apc caner chose cnv copy discovering exon9 fluorophores gastric integer interrogate intron8 losses obtain original platform probe probes searched sought srp19 surrounding taqman transformed variation volunteers yielded
Tagcloud (Intersection) ?