VKORC1 and HSD17B7

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	HSD17B7
Gene Name		vitamin K epoxide reductase complex, subunit 1	hydroxysteroid (17-beta) dehydrogenase 7
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Membrane
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	3-keto Sterol Reductase Activity Estradiol 17-beta-dehydrogenase Activity Prolactin Receptor Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Cholesterol Biosynthetic Process Estrogen Biosynthetic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Cholesterol biosynthesis Metabolism of lipids and lipoproteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol	NADH
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	6 interactors: AGPAT6 BRSK1 CA1 DTYMK GORAB VKORC1
Entrez ID		79001	51478
HPRD ID		10540	05996
Ensembl ID		ENSG00000167397	ENSG00000132196
Uniprot IDs		Q9BQB6	P56937
PDB IDs
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Nucleoside Monophosphate Phosphorylation DTDP Biosynthetic Process Small Molecule Metabolic Process DUDP Biosynthetic Process Glandular Epithelial Cell Maturation Vitamin K Metabolic Process DTTP Biosynthetic Process Cofactor Metabolic Process Deoxyribonucleoside Diphosphate Metabolic Process Nucleoside Diphosphate Biosynthetic Process CDP-diacylglycerol Biosynthetic Process CDP-diacylglycerol Metabolic Process Peptidyl-glutamic Acid Carboxylation Deoxyribonucleotide Biosynthetic Process Diacylglycerol Metabolic Process Nucleobase-containing Small Molecule Interconversion Epithelial Cell Maturation Phosphatidylcholine Biosynthetic Process Phosphatidic Acid Biosynthetic Process Phosphatidic Acid Metabolic Process Deoxyribonucleoside Triphosphate Metabolic Process Regulation Of Body Fluid Levels Glandular Epithelial Cell Development Bicarbonate Transport Secretion Centrosome Duplication G2 DNA Damage Checkpoint One-carbon Metabolic Process Anatomical Structure Development Quinone Metabolic Process Drug Metabolic Process Triglyceride Biosynthetic Process Columnar/cuboidal Epithelial Cell Development Glandular Epithelial Cell Differentiation Myoblast Differentiation Deoxyribonucleotide Metabolic Process Phosphatidylcholine Metabolic Process Pyrimidine Nucleotide Biosynthetic Process Developmental Process Centrosome Cycle Lactation Nucleotide Phosphorylation Response To Cadmium Ion Nucleoside Diphosphate Metabolic Process Acyl-CoA Metabolic Process Cellular Metabolic Process Phosphate-containing Compound Metabolic Process Pyrimidine Nucleotide Metabolic Process Cellular Ketone Metabolic Process Organophosphate Metabolic Process
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	1a akr1c3 androgenic androstenedione comt cyp19a1 cyp1b1 cyp3a5 e1s ers esr2 estrogens extents gper gstp1 hec hieec hsd3b2 hydroxyestrogens ishikawa metabolized nqo2 quinones sulfatase sult1a1 sult2b1 ugt2b7
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	1a akr1c3 androgenic androstenedione comt cyp19a1 cyp1b1 cyp3a5 e1s ers esr2 estrogens extents gper gstp1 hec hieec hsd3b2 hydroxyestrogens ishikawa metabolized nqo2 quinones sulfatase sult1a1 sult2b1 ugt2b7
Tagcloud (Intersection) ?