VKORC1 and CXADR

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	CXADR
Gene Name		vitamin K epoxide reductase complex, subunit 1	coxsackie virus and adenovirus receptor
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Tight Junction Intercalated Disc Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Filopodium Growth Cone Neuromuscular Junction Neuron Projection Protein Complex Cell Body Membrane Raft
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Virus Receptor Activity Receptor Binding Integrin Binding Protein Binding Beta-catenin Binding PDZ Domain Binding Identical Protein Binding Cell Adhesion Molecule Binding Connexin Binding
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Mitochondrion Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Heart Development Blood Coagulation Germ Cell Migration Response To Virus Epithelial Structure Maintenance Viral Process Neutrophil Chemotaxis Actin Cytoskeleton Reorganization Homotypic Cell-cell Adhesion Cell-cell Junction Organization Gamma-delta T Cell Activation Cardiac Muscle Fiber Development Regulation Of Immune Response Leukocyte Migration Defense Response To Virus Transepithelial Transport AV Node Cell To Bundle Of His Cell Communication
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	7 interactors: AMICA1 EWSR1 LNX1 LNX2 NCOA1 NCOR1 VKORC1
Entrez ID		79001	1525
HPRD ID		10540	11804
Ensembl ID		ENSG00000167397	ENSG00000154639
Uniprot IDs		Q9BQB6	P78310
PDB IDs			1EAJ 1F5W 1JEW 1KAC 1P69 1P6A 1RSF 2J12 2J1K 2NPL 2W9L 2WBW
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Regulation Of Glycolytic Process By Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose Monocyte Extravasation Diencephalon Development Regulation Of Body Fluid Levels Regulation Of Lipid Transport By Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Response To Drug CD4-positive, CD25-positive, Alpha-beta Regulatory T Cell Differentiation Neutrophil Extravasation Regulation Of Response To Drug Gamma-delta T Cell Activation Definitive Erythrocyte Differentiation Regulatory T Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Wound Healing Positive Regulation Of Female Receptivity Vitamin K Metabolic Process Male Mating Behavior Protein Homooligomerization Carbon Catabolite Regulation Of Transcription Protein Complex Assembly T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Rhythmic Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Peptidyl-glutamic Acid Carboxylation Thalamus Development Regulation Of Female Receptivity Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Female Mating Behavior Lymphocyte Activation Positive Regulation Of Histone Deacetylation Blood Coagulation Hemostasis Protein Oligomerization Forebrain Development Definitive Hemopoiesis Labyrinthine Layer Morphogenesis Positive Regulation Of Protein Deacetylation Hypothalamus Development Regulation Of Glycolytic Process Leukocyte Activation Embryonic Placenta Morphogenesis Cellular Extravasation
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	biotin breeding btb car cko claudin coxsackievirus fertile fertility fertilize jam junctional knocking lanthanum litter occludin p49 p9 physiology pubertal pups spermatogenesis testicular testis timepoint tracers ultra uncompromised zo1
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	biotin breeding btb car cko claudin coxsackievirus fertile fertility fertilize jam junctional knocking lanthanum litter occludin p49 p9 physiology pubertal pups spermatogenesis testicular testis timepoint tracers ultra uncompromised zo1
Tagcloud (Intersection) ?