VKORC1 and HAMP

Number of citations of the paper that reports this interaction (PMID 21103663)
2

Data Source:
BioGRID (two hybrid)

		VKORC1	HAMP
Gene Name		vitamin K epoxide reductase complex, subunit 1	hepcidin antimicrobial peptide
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Membrane Integral Component Of Membrane	Extracellular Region Apical Cortex
	Molecular Function	Vitamin-K-epoxide Reductase (warfarin-sensitive) Activity Quinone Binding	Hormone Activity
	Biological Process	Blood Coagulation Drug Metabolic Process Peptidyl-glutamic Acid Carboxylation Vitamin K Metabolic Process Post-translational Protein Modification Cellular Protein Metabolic Process Oxidation-reduction Process Bone Development	Cellular Iron Ion Homeostasis Immune Response Killing Of Cells Of Other Organism Defense Response To Bacterium Defense Response To Fungus
Pathways		Post-translational protein modification Gamma carboxylation, hypusine formation and arylsulfatase activation Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
Drugs		Menadione Dicumarol Phenindione Warfarin Phenprocoumon Acenocoumarol
Diseases
GWAS		Warfarin maintenance dose ( 18535201 20833655 19300499)
Protein-Protein Interactions		80 interactors: AHSG APLP2 APOA1 APOA2 APOC1 APOC3 APOC4 ARL6IP5 ASGR1 ASGR2 ATP5G3 ATP6AP2 BCAP31 C1S CCDC12 CCDC167 CD63 CD81 CD9 CLDN10 CNN3 COMT CXADR DPM2 ECHDC1 FGG FGL1 FIS1 FTL GJB1 HAMP HDAC6 HOMER2 HP HPR HSD17B7 IFITM3 JAGN1 KCNK17 LIG4 METTL7B MSMO1 MSRB1 MT1X PCDH1 PCMT1 PDIA6 PIGH PLP2 PPA2 PPIB PROCR REEP5 RMDN1 RMND5A SAA1 SAT1 SERPINA1 SLC15A3 SLC25A1 SLC31A2 SNORA12 SPTSSA STAT6 SURF4 TF TMBIM4 TMEM120A TMEM134 TMEM176A TMEM230 TMEM242 TMEM256 TMEM45B TRAM1 TREX1 VAPB YIF1A ZCCHC24 ZMYM6NB	3 interactors: CKAP4 SLC40A1 VKORC1
Entrez ID		79001	57817
HPRD ID		10540	05925
Ensembl ID		ENSG00000167397
Uniprot IDs		Q9BQB6	P81172
PDB IDs			1M4E 1M4F 2KEF 3H0T
Enriched GO Terms of Interacting Partners?		Cholesterol Metabolic Process Chemical Homeostasis Sterol Metabolic Process Transport Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Phospholipid Efflux Homeostatic Process Steroid Metabolic Process Platelet Degranulation Response To Stress Vesicle-mediated Transport High-density Lipoprotein Particle Remodeling Protein-lipid Complex Assembly Cellular Metal Ion Homeostasis Negative Regulation Of Lipase Activity Cellular Chemical Homeostasis Lipid Metabolic Process Cellular Cation Homeostasis Ion Homeostasis Alcohol Metabolic Process Cellular Homeostasis Cellular Ion Homeostasis Metal Ion Homeostasis Plasma Lipoprotein Particle Remodeling Platelet Activation Cholesterol Efflux Acute Inflammatory Response Positive Regulation Of Cholesterol Esterification Blood Coagulation Hemostasis Plasma Lipoprotein Particle Clearance Regulation Of Cholesterol Transport Lipid Biosynthetic Process Transition Metal Ion Homeostasis Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Transport Acute-phase Response Calcium-mediated Signaling Using Intracellular Calcium Source Lipoprotein Metabolic Process Negative Regulation Of Cholesterol Import Glycerolipid Metabolic Process Defense Response Cell Activation Lipid Homeostasis Reverse Cholesterol Transport Regulation Of Lipid Catabolic Process Regulation Of Cholesterol Import Regulation Of Plasma Lipoprotein Particle Levels Regulation Of Body Fluid Levels Cholesterol Transport	Spleen Trabecula Formation Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Vitamin K Metabolic Process Cellular Response To Iron Ion Peptidyl-glutamic Acid Carboxylation Iron Ion Transmembrane Transport Multicellular Organismal Iron Ion Homeostasis Response To Iron Ion Quinone Metabolic Process Drug Metabolic Process Spleen Development Trabecula Morphogenesis Lymphocyte Homeostasis Iron Ion Transport Cellular Ketone Metabolic Process Cellular Iron Ion Homeostasis Leukocyte Homeostasis Endothelium Development Vitamin Metabolic Process Iron Ion Homeostasis Cellular Response To Metal Ion
Tagcloud ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	anchored bacterial balancing bound communication completely cytosolic delimited diverse domains foreign hamps input intersection language localized machinery membrane modules operate organization output predominantly sensor sensors signal summarized transducers universal
Tagcloud (Difference) ?		arg98trp arginine carboxylase carboxylated carboxylation catalyzes clotting colocalization confocal consequence di disrupts episodes epoxide exits hydroquinone pathophysiology reductase restores silico suffer supplementation supplemented supraphysiological unrelated vitamin vkcfd2 vkd	anchored bacterial balancing bound communication completely cytosolic delimited diverse domains foreign hamps input intersection language localized machinery membrane modules operate organization output predominantly sensor sensors signal summarized transducers universal
Tagcloud (Intersection) ?